Risk Assessment for Manufactured Nanoparticles Used in Consumer Products (RAMNUC)

消费品中使用的人造纳米粒子的风险评估 (RAMNUC)

• 批准号: NE/H012893/1
• 负责人: Kian Fan Chung
• 金额: $ 146.88万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FH012893%2F1
• 关键词: Risk; Assessment; Manufactured; Nanoparticles; Used

Most recent scientific efforts have focused on examining toxicities of manufactured nano-particles (MNPs) only in source materials. By not evaluating MNPs at the point of exposure, these efforts fail to address the relevant question of whether or not consumer-product-derived MNPs are of concern to public health and the environment. The proposed US-UK consortium, 'Risk Assessment for Manufactured Nanoparticles Used in Consumer Products (RAMNUC)', provides a systematic, multidisciplinary approach, including both experimental and computational tools and projects, for predicting potential human and environmental risks associated with the use of selected consumer products that respectively incorporatezinc oxide, silver, and cerium dioxide nanoparticles. The overall hypothesis of the RAMNUC project is that MNPs at the point of exposure for both humans and aquatic animals will substantially differ in both physicochemical and toxicological properties from MNPs at the source (synthesized in the laboratory or acquired commercially). These differences may have significant consequences with respect to MNPs' bioavailability, alterations of immunity, induction of oxidative stress, inflammation, disease processes, and other toxicity measures. We will assess intracellular and extracellular bioavailability and toxicity of the selected MNPs, as synthesized and as incorporated in consumer products, using both in vitro and in vivo experiments. Tested MNPs will be controlled or well characterized for their physical (e.g., size, shape, state of agglomeration/aggregation) and chemical properties (e.g., composition, functionalization, surface chemistry). Hence, our proposed in vitro and in vivo studies will produce mechanism-based results relating toxic effects to MNP physicochemical properties. The RAMNUC Consortium will also include a novel human exposure simulation study that will produce realistic estimates of MNP exposures to consumers. Data generated from these mechanistic experiments will be integrated into the mechanism-based computational modules of two existing source-to-exposure-dose-to-effects modeling systems, allowing for rational extrapolation and generalization in MNP risk assessment. Built upon the inter-institutional expert structure, the RAMNUC consortium serves as a model for systematically addressing complex problems associated with MNP risk assessment and will generate results that will contribute to our very limited knowledge about health risks associated with the use of nano-technology based consumer products.

最近的科学努力主要集中在检查人造纳米颗粒（MNPs）的毒性，仅在源材料中。由于没有在接触点对MNPs进行评估，这些努力未能解决消费产品衍生的MNPs是否会对公共卫生和环境造成影响的相关问题。拟议中的美英联盟，“用于消费品的人造纳米颗粒风险评估（RAMNUC）”，提供了一个系统的，多学科的方法，包括实验和计算工具和项目，用于预测与使用分别含有氧化锌，银和二氧化铈纳米颗粒的选定消费品相关的潜在人类和环境风险。RAMNUC项目的总体假设是，人类和水生动物接触点的MNPs在物理化学和毒理学特性方面与源头（实验室合成或商业获取）的MNPs有很大不同。这些差异可能对MNPs的生物利用度、免疫改变、氧化应激诱导、炎症、疾病过程和其他毒性措施产生重大影响。我们将通过体外和体内实验评估所选MNPs的细胞内和细胞外生物利用度和毒性，无论是合成的还是加入到消费品中。测试的MNPs将被控制或很好地表征其物理（例如，大小，形状，团聚/聚集状态）和化学性质（例如，组成，功能化，表面化学）。因此，我们提出的体外和体内研究将产生与MNP物理化学性质有关的毒性作用的基于机制的结果。RAMNUC联盟还将包括一项新的人体暴露模拟研究，该研究将产生对消费者接触MNP的现实估计。从这些机制实验中产生的数据将被整合到两个现有源-暴露-剂量-效应建模系统的基于机制的计算模块中，从而允许在MNP风险评估中进行合理的外推和推广。RAMNUC联盟建立在机构间专家结构的基础上，可作为一个模型，系统地解决与纳米材料风险评估相关的复杂问题，并将产生结果，有助于我们了解与使用基于纳米技术的消费品相关的健康风险，这方面的知识非常有限。

项目成果

High resolution and dynamic imaging of biopersistence and bioreactivity of extra and intracellular MWNTs exposed to microglial cells.

• DOI: 10.1016/j.biomaterials.2015.08.019
• 发表时间: 2015-11
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Goode AE;Gonzalez Carter DA;Motskin M;Pienaar IS;Chen S;Hu S;Ruenraroengsak P;Ryan MP;Shaffer MS;Dexter DT;Porter AE
• 通讯作者: Porter AE

The stability of silver nanoparticles in a model of pulmonary surfactant.

• DOI: 10.1021/es403377p
• 发表时间: 2013-10-01
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Leo, Bey Fen;Chen, Shu;Kyo, Yoshihiko;Herpoldt, Karla-Luise;Terrill, Nicholas J.;Dunlop, Iain E.;McPhail, David S.;Shaffer, Milo S.;Schwander, Stephan;Gow, Andrew;Zhang, Junfeng;Chung, Kian Fan;Tetley, Teresa D.;Porter, Alexandra E.;Ryan, Mary P.
• 通讯作者: Ryan, Mary P.

High-resolution analytical electron microscopy reveals cell culture media-induced changes to the chemistry of silver nanowires.

• DOI: 10.1021/es403264d
• 发表时间: 2013-12-03
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Chen, Shu;Theodorou, Ioannis G.;Goode, Angela E.;Gow, Andrew;Schwander, Stephan;Zhang, Junfeng (Jim);Chung, Kian Fan;Tetley, Teresa D.;Shaffer, Milo S.;Ryan, Mary P.;Porter, Alexandra E.
• 通讯作者: Porter, Alexandra E.

Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats.

• DOI: 10.1021/acsnano.6b07313
• 发表时间: 2017-03-28
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Chung KF;Seiffert J;Chen S;Theodorou IG;Goode AE;Leo BF;McGilvery CM;Hussain F;Wiegman C;Rossios C;Zhu J;Gong J;Tariq F;Yufit V;Monteith AJ;Hashimoto T;Skepper JN;Ryan MP;Zhang J;Tetley TD;Porter AE
• 通讯作者: Porter AE

Advancing the Understanding of Environmental Transformations, Bioavailability and Effects of Nanomaterials, an International US Environmental Protection Agency-UK Environmental Nanoscience Initiative Joint Program.

• DOI: 10.4236/jep.2018.94025
• 发表时间: 2018-04-02
• 期刊: Journal of environmental protection
• 作者: Lasat MM;Chung KF;Lead J;McGrath S;Owen RJ;Rocks S;Unrine J;Zhang J
• 通讯作者: Zhang J