'COVAIR': Is SARS-CoV-2 airborne and does it interact with particle pollutants?

“COVAIR”：SARS-CoV-2 是否通过空气传播？它是否与颗粒污染物相互作用？

• 批准号: EP/V052462/1
• 负责人: Kian Fan Chung
• 金额: $ 65.74万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV052462%2F1
• 关键词: COVAIR; SARS; CoV; airborne; does

Aerosol dispersion and environmental spread of SARS-CoV2 virus apart from direct inhalation oflarge droplets from a cough or exhaled breath of an infected person remains a high possibility.SARS-CoV2 virus has been collected from the air of hospitals with COVID-19 patients and thepresence of the virus on particulate matter has been reported in Northern Italy. We wish todevelop diagnostic tools and predictive sensing to detect SARS-CoV2 in crowded urbanenvironments in order to address whether the airborne amounts are high enough to cause arespiratory infection and whether pollution particles can carry live virus that is directly inhaled intothe lungs. We will determine whether SARS-CoV2 can be detected as active virus in the air ofhospitals with COVID-19 patients, and if so, use a similar technique to measure the virus incrowded spaces such as in underground train platforms, central station concourse, shopping mallsand busy roadside. We will use and validate different methods of collecting particles fromexperience obtained from our EPSRC-funded INHALE project. Particles will be collected onto filters,and virus and virus-particulate interactions determined by RT-PCR (RNA-based), culturing on VeroE6 cells and airway epithelial cells, and using state-of-the -art electron microscopy. We will modelthis mode of transmission into the lungs by studying airflows and pollutant levels, and as ameasure of this infection in the population. This method can be potentially considered as asurveillance assay of crowded public areas for SARS-CoV2 with ~ 2,000 new infections currentlyreported daily.

除了直接吸入感染者咳嗽或呼出的大飞沫外，SARS-CoV2病毒的气溶胶扩散和环境传播的可能性仍然很高。已从有COVID-19患者的医院的空气中收集到SARS-CoV2病毒，据报道，意大利北部的颗粒物中存在该病毒。我们希望开发诊断工具和预测传感，在拥挤的城市环境中检测SARS-CoV2，以解决空气中的数量是否高到足以引起呼吸道感染，以及污染颗粒是否可以携带活病毒直接吸入肺部。我们将确定在有COVID-19患者的医院的空气中是否可以检测到SARS-CoV2为活性病毒，如果可以，使用类似的技术测量地铁站台、中央车站大厅、购物中心和繁忙的路边等拥挤空间的病毒。我们将根据epsrc资助的吸气项目获得的经验，使用和验证不同的颗粒收集方法。颗粒将被收集到过滤器上，通过RT-PCR（基于rna的）、在VeroE6细胞和气道上皮细胞上培养以及使用最先进的电子显微镜来确定病毒和病毒颗粒之间的相互作用。我们将通过研究气流和污染物水平来模拟这种进入肺部的传播模式，并作为人群中这种感染的测量。该方法可作为目前每天报告约2000例新感染病例的拥挤公共区域的SARS-CoV2监测试验。

项目成果

The miR-196a SNP Rs11614913 but not the miR-499 rs37464444 SNP is a Risk Factor for Non-small Cell Lung Cancer in an Iranian Population

miR-196a SNP Rs11614913 但不是 miR-499 rs37464444 SNP 是伊朗人群非小细胞肺癌的危险因素

• 发表时间: 2022
• 期刊: Tanaffos
• 作者: Dezfuli N.K.

SARS-CoV2 in public spaces in West London, UK during COVID-19 pandemic.

• DOI: 10.1136/bmjresp-2022-001574
• 发表时间: 2023-05
• 期刊: BMJ open respiratory research
• 影响因子: 4.1

Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units.

• DOI: 10.3389/fnut.2022.975937
• 发表时间: 2022
• 期刊: FRONTIERS IN NUTRITION
• 影响因子: 5
• 作者: Hashemian, Seyed MohammadReza;Mortaz, Esmaeil;Shafigh, Navid;Ziaie, Shadi;Jamaati, Hamidreza;Hasheminik, Morteza;Jamalinik, Mehdi;Erfani, Raziyeh;Khoundabi, Batoul;Dezfuli, Neda K.;Varahram, Mohammad;Ahmadi, Shahrzad;Fahimi, Mahdi;Adcock, Ian M.
• 通讯作者: Adcock, Ian M.

Angiogenic effects of cell therapy within a biomaterial scaffold in a rat hind limb ischemia model.

• DOI: 10.1038/s41598-021-99579-0
• 发表时间: 2021-10-15
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Amani S;Shahrooz R;Hobbenaghi R;Mohammadi R;Baradar Khoshfetrat A;Karimi A;Bakhtiari Z;Adcock IM;Mortaz E
• 通讯作者: Mortaz E

IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma.

• DOI: 10.1111/all.15487
• 发表时间: 2023-01
• 期刊: ALLERGY
• 影响因子: 12.4
• 作者: Badi, Yusef Eamon;Salcman, Barbora;Taylor, Adam;Rana, Batika;Kermani, Nazanin Zounemat;Riley, John H.;Worsley, Sally;Mumby, Sharon;Dahlen, Sven-Eric;Cousins, David;Silvia, Bulfone-Paus;Affleck, Karen;Chung, Kian Fan;Bates, Stewart;Adcock, Ian M.
• 通讯作者: Adcock, Ian M.