PROSTATE CANCER RISK IN RELATION TO NUTRITION

童年或青春期营养习惯的假设 （特别是能量和/或脂肪摄入）可能与增加的 前列腺癌风险，可能通过体型和/或体重介导 在特定的生命周期中，目前正在增加 关注 拟议调查的目的是检验这一点 一项前瞻性队列研究中的假设。 要定义潜在的关键 暴露期本研究将特别关注 进行了饮食限制。 这项调查利用了荷兰的独特环境， 前列腺癌是常见的西方人群。 在这个国家， 很大一部分人口面临严重的饥荒 第二次世界大战结束时（1944-1945）。 此外，营养是 在经济危机期间，尽管程度较轻， 20世纪30年代和战争占领的早期， 在1940年1986年，58，279名年龄在55-69岁之间的男性被招募， 一项关于荷兰饮食与癌症风险的队列研究。 一 这些人中有相当一部分经历了经济萧条， 童年时期的战争事件 这些暴露对身体的影响 将研究前列腺癌的发病率， 儿童营养与诊断阶段之间的关系。 这次调查的结果将提供高度相关的 关于儿童期能量限制 和随后的前列腺癌风险， 成年男性的样本。

The hypothesis that nutritional habits in childhood or adolescence (particularly energy and/or fat intake) may be associated with increased prostate cancer risk, possibly mediated through body size and/or weight gain during particular periods of life, is currently receiving increased attention. The purpose of the proposed investigation is to test this hypothesis in a prospective cohort study. To define potential critical exposure periods this study will specifically focus on the age at which dietary restriction took place. This investigation utilizes the unique setting in the Netherlands, a western population where prostate cancer is common. In this country, a substantial part of the population was exposed to a severe famine towards the end (1944-1945) of World War II. In addition, nutrition was compromised, albeit to a lesser degree, during the economic crisis of the 1930s and in the early years of the wartime occupation which started in 1940. In 1986, 58,279 men between the ages 55-69 were recruited for a cohort study on diet and cancer risk in the Netherlands. A substantial number of these men experienced the economic depression and the wartime events in childhood. The impact of these exposures on body size and prostate cancer incidence will be studied, as will the association between childhood nutrition and stage at diagnosis. The results of this investigation will provide highly relevant prospective data on the relation between energy restriction in childhood and subsequent prostate cancer risk in a nationally representative sample of adult men.