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Prenatal Under Nutrition and Mortality Through Age 63 Project

Prenatal Under Nutrition and Mortality Through Age 63 Project
产前营养不足和 63 岁死亡率项目
批准号:
8816986
负责人:
L H LUMEY
金额:
$50.63万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-04-01 至 2016-12-31

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中文摘要
翻译
描述(由申请人提供):1944-1945年的荷兰饥荒(“饥饿的冬天”)提供了一个独特的机会来确定生命过程健康和福祉的早期决定因素。迄今为止,研究集中在20世纪60年代初对大约45,000名18岁新兵的健康和死亡率结果进行了检查。从这些人的出生地点和日期可以推断出他们受饥荒的程度。现在需要资金来将政府来源的各种社会经济结果(就业、工资和残疾福利)与我们研究的人群联系起来。这项研究是流行病学家、人口学家和经济学家(赫克曼博士,芝加哥大学)的合作成果。新的关联数据将用最先进的流行病学和计量经济学方法进行分析,以可靠地识别、估计和解释整个生命周期中早期生命冲击的影响。这项工作将
英文摘要
DESCRIPTION (provided by applicant): The Dutch Famine ('Hunger Winter') of 1944-1945 provides a unique opportunity to identify early life determinants of life course health and well-being. To date, studies have concentrated on health and mortality outcomes in ~45,000 army recruits who were examined at age 18 in the early 1960s. Famine exposure in these men can be inferred from place and date of birth. Funding is now requested to link a wide variety of socio-economic outcomes (employment, wages, and disability benefits) from government sources to our studied population. The study is collaboration between epidemiologists and demographers and economists (Dr. Heckman, University of Chicago). The newly linked data will be analyzed with state-of-the-art epidemiologic and econometric approaches to reliably identify, estimate, and interpret the effects of an early life shock throughout the lifecycle. This work will integrate currently separated research traditions from the medical and social sciences and lead to a better understanding of 'fetal programming' and its implications.
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Prenatally induced DNA methylation profiles and disease risk at age 60
Prenatally induced DNA methylation profiles and disease risk at age 60
Prenatally induced DNA methylation profiles and disease risk at age 60
Exploring persistent epigenetic changes after prenatal famine exposure in humans
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