PROSTATE CANCER RISK RELATED TO CHILDHOOD NUTRITION

儿童或青春期的营养习惯假说 (特别是能量和/或脂肪摄入量)可能与增加 前列腺癌风险，可能通过体型和/或体重进行调节 在生命的特定时期获得的收益，目前正在增加 请注意。拟议调查的目的就是检验这一点。 前瞻性队列研究中的假设。定义潜在的危急情况 暴露期这项研究将特别关注年龄 饮食限制发生了。 这项调查利用了荷兰独特的背景，一种 前列腺癌常见的西方人群。在这个国家， 相当一部分人口遭受了严重的饥荒 在第二次世界大战结束时(1944-1945)。此外，营养是 在#年的经济危机期间，尽管程度较小，但受到了损害 20世纪30年代和开始的战时占领的早期 1940年。1986年，58,279名年龄在55-69岁之间的男性被招募到 荷兰一项关于饮食与癌症风险的队列研究。一个 这些人中有相当一部分经历了经济萧条和 童年时期的战时事件。这些暴露对人体的影响 将研究体型和前列腺癌发病率，以及 儿童营养与诊断分期的关系。 这次调查的结果将提供高度相关的 儿童时期能量限制关系的前瞻性数据 和随后的前列腺癌风险在全国具有代表性的 成年男性样本。

The hypothesis that nutritional habits in childhood or adolescence (particularly energy and/or fat intake) may be associated with increased prostate cancer risk, possibly mediated through body size and/or weight gain during particular periods of life, is currently receiving increased attention. The purpose of the proposed investigation is to test this hypothesis in a prospective cohort study. To define potential critical exposure periods this study will specifically focus on the age at which dietary restriction took place. This investigation utilizes the unique setting in the Netherlands, a western population where prostate cancer is common. In this country, a substantial part of the population was exposed to a severe famine towards the end (1944-1945) of World War II. In addition, nutrition was compromised, albeit to a lesser degree, during the economic crisis of the 1930s and in the early years of the wartime occupation which started in 1940. In 1986, 58,279 men between the ages 55-69 were recruited for a cohort study on diet and cancer risk in the Netherlands. A substantial number of these men experienced the economic depression and the wartime events in childhood. The impact of these exposures on body size and prostate cancer incidence will be studied, as will the association between childhood nutrition and stage at diagnosis. The results of this investigation will provide highly relevant prospective data on the relation between energy restriction in childhood and subsequent prostate cancer risk in a nationally representative sample of adult men.