BIODEGRADABLE POLYMERIC PRODRUGS

可生物降解的聚合物前药

• 批准号: 6198933
• 负责人: KATHRYN Elizabeth UHRICH
• 金额: $ 18.91万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6198933
• 关键词: biodegradable product; biomaterial development /preparation; biomaterial evaluation; dental agent; drug delivery systems; inflammation; laboratory mouse; periodontium; periodontium disorder; polymers; prodrugs; salicylate; slow release drug

DESCRIPTION (Adapted from the application): This proposal will investigate a new mode for treatment of periodontal diseases. Periodontal diseases comprise a group of related microbial-induced chronic inflammatory disorders that destroy the tissue supporting the teeth. The diseases can result in loss of normal soft and hard tissue architecture at sites adjacent to the affected teeth. The goals of this project are: to accelerate the recovery/restoration of new, healthy periodontal architecture; to reduce post-operative pain after periodontal surgery; and to reduce local pH to create an unfavorable environment for periodontic bacteria. The poly(anhydride-esters)(PAE's) described within are biodegradable (bioresorbable) materials that can be used for short-term dental treatments. The proposal is a demonstrator project for future applications in novel dental biomaterial technology. This system is the first example in which the polymer itself is a controlled-release system; the polymer membrane degrades into salicylic acid (SA), which has analgesic properties. The investigators anticipate that PAE's will simultaneously serve three purposes: accelerating the recovery/restoration of new, healthy periodontal architecture; reducing post-operative pain after periodontal surgery; and reducing local pH to create an unfavorable environment for periodontic bacteria. However, this Proposal focuses on what the investigators consider the most significant aspect of this novel degradable polymer-localized reduction of inflammation and restoration of healthy periodontal architecture. The goals of the proposal are to evaluate the ability of poly(anhydride-esters) to simultaneously reduce inflammation while restoring periodontal tissues. As a function of in vivo polymer degradation, the investigators address the following hypotheses: Does SA reduce the inflammatory response? Is SA observed systemically? Can the release of SA be controlled? Do the polymers restore healthy periodontal architecture? The overall objective of this proposal is to determine if the local delivery of SA via degradable PAE's will simultaneously reduce inflammation and restore healthy periodontal architecture.

描述(改编自申请)：该提案将调查 牙周病治疗的新模式。牙周病包括 一组相关的微生物诱导的慢性炎症性疾病 支持牙齿的组织。这些疾病会导致正常软组织的丧失。 和受影响牙齿邻近部位的硬组织结构。目标 这个项目的目的是：加速恢复/恢复新的、健康的 牙周结构；减少牙周术后疼痛 手术；以及降低局部PH值，创造不利的环境 牙周病细菌。 其中所述的聚酸酐-酯(PAE)是可生物降解的 (可生物吸收的)可用于短期牙科治疗的材料。 该方案是未来在新型牙科领域应用的示范项目 生物材料技术。该系统是第一个将聚合物 本身是一个控制释放系统；聚合物膜降解成 水杨酸(SA)，具有止痛特性。调查人员 预计PAE将同时服务于三个目的：加速 恢复/修复新的、健康的牙周结构；减少 牙周手术后疼痛；降低局部酸碱度以创造 不利于牙周病细菌生长的环境。然而，这项提议 重点关注调查人员认为这一事件中最重要的方面 新型可降解聚合物--局部消炎修复 健康的牙周结构。该提案的目标是评估 聚酸酐-酯同时减轻炎症的能力 修复牙周组织。作为体内聚合物降解的函数， 调查人员提出了以下假设： SA是否能减少炎症反应？ 是否有系统地观察SA？ SA的释放能被控制吗？ 这种聚合物能恢复健康的牙周结构吗？ 这项提案的总体目标是确定是否在当地交付 通过可降解的PAE的SA将同时减少炎症和恢复 健康的牙周结构。