BIODEGRADABLE POLYMERIC PRODRUGS

可生物降解的聚合物前药

• 批准号: 6606155
• 负责人: KATHRYN Elizabeth UHRICH
• 金额: $ 16.14万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6606155
• 关键词: biodegradable product; biomaterial development /preparation; biomaterial evaluation; dental agent; drug delivery systems; inflammation; laboratory mouse; periodontium; periodontium disorder; polymers; prodrugs; salicylate; slow release drug

DESCRIPTION (Adapted from the application): This proposal will investigate a new mode for treatment of periodontal diseases. Periodontal diseases comprise a group of related microbial-induced chronic inflammatory disorders that destroy the tissue supporting the teeth. The diseases can result in loss of normal soft and hard tissue architecture at sites adjacent to the affected teeth. The goals of this project are: to accelerate the recovery/restoration of new, healthy periodontal architecture; to reduce post-operative pain after periodontal surgery; and to reduce local pH to create an unfavorable environment for periodontic bacteria. The poly(anhydride-esters)(PAE's) described within are biodegradable (bioresorbable) materials that can be used for short-term dental treatments. The proposal is a demonstrator project for future applications in novel dental biomaterial technology. This system is the first example in which the polymer itself is a controlled-release system; the polymer membrane degrades into salicylic acid (SA), which has analgesic properties. The investigators anticipate that PAE's will simultaneously serve three purposes: accelerating the recovery/restoration of new, healthy periodontal architecture; reducing post-operative pain after periodontal surgery; and reducing local pH to create an unfavorable environment for periodontic bacteria. However, this Proposal focuses on what the investigators consider the most significant aspect of this novel degradable polymer-localized reduction of inflammation and restoration of healthy periodontal architecture. The goals of the proposal are to evaluate the ability of poly(anhydride-esters) to simultaneously reduce inflammation while restoring periodontal tissues. As a function of in vivo polymer degradation, the investigators address the following hypotheses: Does SA reduce the inflammatory response? Is SA observed systemically? Can the release of SA be controlled? Do the polymers restore healthy periodontal architecture? The overall objective of this proposal is to determine if the local delivery of SA via degradable PAE's will simultaneously reduce inflammation and restore healthy periodontal architecture.

描述（改编自应用程序）：本提案将调查 牙周病治疗的新模式。牙周病包括 一组相关的微生物引起的慢性炎症性疾病， 支撑牙齿的组织这些疾病会导致正常的软组织丧失， 和邻近受影响牙齿的硬组织结构。的目标 该项目的目的是：加速恢复/恢复新的，健康的 牙周结构;减少牙周术后疼痛 手术;以及降低局部pH值以创造不利的环境， 牙周炎细菌 其中所述的聚（酸酐-酯）（PAE）是可生物降解的 （生物可吸收的）材料可用于短期牙科治疗。 该提案是一个示范项目，为未来的应用，在新的牙科 生物材料技术该系统是第一个例子，其中聚合物 它本身是一个控释系统;聚合物膜降解成 水杨酸（SA），具有镇痛作用。调查人员 预计PAE将同时服务于三个目的：加速 恢复/恢复新的，健康的牙周结构;减少 牙周手术后的术后疼痛;以及降低局部pH值， 对牙周细菌不利的环境。但这一提议 重点关注调查人员认为最重要的方面， 新的可降解聚合物-局部减少炎症和恢复 健康的牙周结构。该提案的目标是评估 聚（丙二醇酯）同时减少炎症的能力， 修复牙周组织。作为体内聚合物降解的函数， 调查人员提出了以下假设： SA是否减少炎症反应？ 是否系统性观察到SA？ SA的释放是否可以控制？ 聚合物能恢复健康的牙周结构吗？ 本提案的总体目标是确定当地是否提供 SA通过可降解的PAE将同时减少炎症和恢复 健康的牙周结构。