Differentiation, electrical activity and synapse structure of human stem cell-derived sensory neurons

人类干细胞来源的感觉神经元的分化、电活动和突触结构

• 批准号: nhmrc : 1023372
• 负责人: Dr Bryony Nayagam
• 金额: $ 21.48万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/differentiation-electrical-activity-sensory-neurons/110270
• 关键词: Differentiation; electrical; activity; synapse; structure

A major challenge in treating neurodegenerative conditions with stem cells, is to generate a population of donor cells which are capable of incorporating into the host nervous system and restoring function. This proposal will test the capacity of human stem cells to make functional connections in the auditory system, potentially enhancing hearing with a cochlear implant. These studies are critical in determining how stem cells may be used to promote functional regeneration of the damaged nervous system.

用干细胞治疗神经退行性疾病的主要挑战是产生能够并入宿主神经系统并恢复功能的供体细胞群。这项提案将测试人类干细胞在听觉系统中建立功能性连接的能力，从而有可能通过人工耳蜗增强听力。这些研究对于确定干细胞如何用于促进受损神经系统的功能再生至关重要。