TRAINING PROGRAM IN BIOORGANIC CHEMISTRY

生物有机培训补助金现已提交续期， 在布兰迪斯的科学教育中发挥了重要作用。掀起 给一群有着新奇兴趣和新奇想法的研究生 能力的这个项目的目标是培训调查人员， 可以在生物学、生物化学和化学的中间阶段工作。 我们 都取得了成功很明显，从听轮换报告， 化学家可以使用，并了解分子生物学技术， 生物学家可以合成化合物。这种技能的组合是 制药行业的需求，并应促进未来 健康相关的研究。这个项目一开始没有学生， 有18名学生。实习生的任命取决于他们的实力 学习成绩和研究能力的证明。 上 一年的研究生培训，他们开始参加一个项目， 由七门课程组成的核心课程。学生们把这些 课程的前两年。核心课程 包括两个学期的高级生物化学（生物化学101A & 101B），一个学期的高级有机合成（化学134），一 分子生物学（生物学105）一学期，机械学一学期 有机化学（选自化学131，133或生物化学） 202），光谱学高级课程的一个学期，或 晶体结构测定（选自化学132， 229，或235），最后一个选修课，从产品中选择， 化学，生物化学，生物学或神经科学课程。 第一年 学生们也要在不同的实验室进行六周的轮换， 在节目中。学生们必须完成一半的轮换， 这些问题集中在化学合成上。这可以通过 在化学系教师的实验室轮换， 适当时，在生物化学部门的实验室进行。一 论文最后给出了研究结果的书面报告和口头报告 每一个旋转。轮换的目的是双重的。第一， 让学生接触到许多不同的教师，以促进 他们选择的导师，并给他们一个广泛的经验，不同的 解决科学问题的方法。第二，轮换是一种手段， 确保我们所有的学生在早期的实践综合经验， 科学事业。此外，学生还参加研讨会， 在整个逗留期间的日记。

The Bioorganic Training Grant, which is now submitted for renewal, has played an important role in science education at Brandeis. It gave rise to a group of graduate students with novel interests and novel capabilities. It was the goal of this program to train investigators who can work at the interphase of biology, biochemistry, and chemistry. We have been successful. It is apparent, from listening to rotation reports, that chemists can use, and understand techniques of molecular biology, and biologists can synthesize compounds. This combination of skills is in demand by the pharmaceutical industry, and should facilitate future health related research. The program started with zero students and now contains 18 students. Trainees are appointed on the basis of their strong academic record and evidence of their research ability. In the first year of graduate training they begin to participate in a program, which consists of a core curriculum of seven courses. Students take these courses in their first two years of the program. The core curriculum consists of two semesters of Advanced Biochemistry (Biochemistry 101A & 101B), one semester of Advanced Organic Synthesis (Chemistry 134), one semester of Molecular Biology (Biology 105), one semester of Mechanistic Organic Chemistry (selected from Chemistry 131, 133, or Biochemistry 202), one semester of an advance course in spectroscopy or crystallographic structure determination (selected from Chemistry 132, 229, or 235), and finally one elective, selected from offerings in the Chemistry, Biochemistry, Biology or Neuroscience programs. First year students also undertake six, six-week rotations in different laboratories in the program. The students must complete half of their rotations on problems which focus on chemical synthesis. This can be accomplished by rotating in laboratories of faculty from the Chemistry Department or, where appropriate, in laboratories from the Biochemistry Department. A written report and oral presentation of the results are given at the end of each rotation. The purpose of the rotations is two-fold. First, is to give students exposure to many different faculty so as to facilitate their choice of mentor and to give them a broad experience with different approaches to scientific problems. Second, the rotations are a means of ensuring hands-on synthesis experience for all of our students early in the scientific careers. In addition students participate in seminars and journal clubs throughout their stay.