Macromolecular Structure and Mechanism

项目摘要 该培训计划为研究生提供了原则方面的高级教育 高分子化学、机理和结构的实践。的所有方面 程序-正式课程，实验室轮换，非正式专业领域-兴趣 研讨会，并在实验室进行深入的研究，在发现的边缘-旨在 生物大分子是如何工作的蛋白质，细胞膜， 核酸和这些巨大分子的高级复合物使用物理化学和 结构原则在构成生物功能基础的各种各样的环境中起作用？ 该培训计划为研究生课程的选定学生提供支持， 布兰迪斯大学生物化学和生物物理学。这是一个灵活的博士课程设计， 两大类学生：那些有很强的量化背景，但谁可能有 较弱的生物化学培训经验，以及那些接受过更多传统培训的人 生物化学和细胞生物学。我们的目的是把这两组学生带到 同样的终点，并为他们在基础研究的职业生涯做好准备。目前，34名学生 就读于这个博士学位计划;培训计划包括25名参与教师，从四个 部门，在以下领域开展工作：用X射线测定高分子结构 晶体学和核磁共振，机械酶学，生物无机化学，强调EPR 和穆斯堡尔谱，膜运输和离子通道机制，单- 分子分析、病毒学、化学生物学、计算生物物理学和蛋白质进化。

Project Summary This Training Program provides graduate students with advanced education in the principles and practice of macromolecular chemistry, mechanism, and structure. All aspects of the program - formal course curriculum, laboratory rotations, informal specialized area-interest seminars, and intensive research in laboratories operating on the edge of discovery - are aimed at the question: how do biological macromolecules work? How do proteins, membranes, nucleic acids, and high-order complexes of these huge molecules use physical-chemical and structural principles to act in the enormous variety of contexts that underlie biological function? The Training Program provides support for selected students in the Graduate Program in Biochemistry and Biophysics at Brandeis University. This is a flexible PhD program designed for two broad types of students: those with strong quantitative backgrounds but who may have weaker prior training experience in biological chemistry, and those with more traditional training in biochemistry and cell biology. Our intention is to bring these two groups of students to the same end-point and to prepare them for careers in basic research. Currently, 34 students are enrolled in this Ph.D. program; the Training Program includes 25 participating faculty, from four departments, working in the following areas: macromolecular structure determination by x-ray crystallography and NMR, mechanistic enzymology, bioinorganic chemistry emphasizing epr and Mössbauer spectroscopy, membrane transport and ion channel mechanisms, single- molecule analysis, virology, chemical biology, computational biophysics, and protein evolution.