TRAINING GRANT IN MOLECULAR BIOPHYSICS

请求为继续支持罗格斯大学分子生物物理学跨学科培训方案提供资金。该课程提供了解决分子生物物理学问题所需的实验和理论技术的广泛接触，以及与特定研究问题的深入培训。罗格斯大学的研究生教师包括该国最大和最活跃的分子生物物理学家团体之一，他们的兴趣范围从分子和亚分子问题到细胞组织和完整生物体的各个方面。培训人员分布在罗格斯大学的四个研究生项目和罗格斯大学的七个系，以及邻近的新泽西医学和牙科大学罗伯特·伍德·约翰逊医学院(前身为罗格斯医学院)。有重要的研究项目包括X射线结晶学和衍射学(Edward Arnold，Helen M.Berman，Barbara M.Brodsky，Millie M.Georgiadis，Ann Stock)，核磁共振(Jean S.Baum，Gaetano T.Montelione)，理论方法(Karsten Krogh-Jesman，Ronald M.Levy，Gerald S.Manning，Wilma K.Olson)，人工智能(Casimir A.Kulikowski，Martin Farach)，连续介质力学(Bernard D.Coleman)，生物热力学和光谱学(Kenneth J.Breslaer，Jeehiun K.Lee)。电子显微镜(Donald A.Winkelmann)和生化合成与设计(Stephen Anderson、Richard H.Ebright、Marc R.Gartenberg、Sarah E.Hitchcock-Dregori、Masayori Inouye、Stephen S.Isied、Roger A.Jones、John W.Taylor)。这些教师是一个紧密联系的群体，在大分子结构、功能和相互作用方面有着共同的兴趣，并有着卓有成效的相互作用的历史。未来的受训者拥有生物、化学、计算机科学、工程、数学和物理方面的本科学位。该项目包括正式的研究生课程、实验室轮换、研讨会和论文研究。研究小组装备精良，并得到来自外部来源的良好支持。资深教员在培养学生方面拥有丰富的经验，初级教员是全国最有前途的年轻科学家之一。学术氛围很好，有利于培养未来的研究机会。罗格斯大学和牙科大学拥有卓越的计算、成像、核磁共振和X射线设备，可用于分子生物物理学方面的培训。这两所大学还与新泽西州科学技术委员会共同发起了新泽西州高级生物技术和医学中心，该中心专注于分子生物物理学的研究。该培训计划不仅有助于满足国家对接受过将物理科学的工具和概念应用于解决重大生物学问题的人员的需求，还有助于改善罗格斯大学的学术环境。申请的资金有助于吸引一批优秀的博士前学生，统一现有的研究生课程，并提供分子生物物理学方面的独立研究生课程。

Funding is requested for continued support of an interdisciplinary training program in molecular biophysics at Rutgers University. The program offers broad exposure to the experimental and theoretical techniques needed to solve problems in molecular biophysics together with in-depth training with a specific research problem. The graduate faculty of Rutgers University includes one of the largest and most active groups of molecular biophysicists in the country with interests ranging from molecular and submolecular problems to aspects of cellular organization and intact organisms. The training faculty are spread over four graduate programs at Rutgers and seven departments at Rutgers and the adjacent Robert Wood Johnson Medical School (formerly Rutgers Medical School) of the University of Medicine and Dentistry of New Jersey. There are significant research programs in X-ray crystallography and diffraction (Edward Arnold, Helen M. Berman, Barbara M. Brodsky, Millie M. Georgiadis, Ann Stock), nuclear magnetic resonance (Jean S. Baum, Gaetano T. Montelione), theoretical methods (Karsten Krogh- Jesperson, Ronald M. Levy, Gerald S. Manning, Wilma K. Olson), artificial intelligence (Casimir A. Kulikowski, Martin Farach), continuum mechanics (Bernard D. Coleman), biothermodynamics and spectroscopy (Kenneth J. Breslauer, Jeehiun K. Lee. Richard Ludescher, Tariq M. Rana, T.J. Thomas), electron microscopy (Donald A. Winkelmann), and biochemical synthesis and design (Stephen Anderson, Richard H. Ebright, Marc R. Gartenberg, Sarah E. Hitchcock-Dregregori, Masayori Inouye, Stephen S. Isied, Roger A. Jones, John W. Taylor). The faculty are a closely knit group with common interests in macromolecular structure, function, and interactions and with a history of fruitful interactions. Prospective trainees enter with undergraduate degrees in biology, chemistry, computer science, engineering, mathematics and physics. The program entails formal graduate courses, laboratory rotations, seminars, and dissertation research. Research groups are well equipped and well supported from extramural sources. The senior faculty have extensive experience in training students and the junior faculty are among the most promising young scientists in the nation. The intellectual climate is excellent and conducive to nurturing future research opportunities. Rutgers University and the University of Medicine of Dentistry have outstanding computational, imaging, NMR, and X-ray facilities available for training in molecular biophysics. The universities, together with the New Jersey Commission on Science and Technology, also jointly sponsor the New Jersey Center for Advanced Biotechnology and Medicine which has a strong research focus in molecular biophysics. The training program not only helps to meet national needs for personnel trained to apply the tools and concepts of the physical sciences to the solution of significant biological problems but also helps to enhance the academic environment within Rutgers University. The requested funds help to attract a pool of outstanding predoctoral students, to unify existing graduate offerings, and to offer an independent graduate curriculum in molecular biophysics.