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CHARACTERIZATION OF THE RHODOPSIN/TRANSDUCIN INTERFACE

CHARACTERIZATION OF THE RHODOPSIN/TRANSDUCIN INTERFACE
视紫红质/转导蛋白界面的表征
批准号:
6164714
负责人:
Garland Ross Marshall
金额:
$20.67万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-03-01 至 2002-02-28

项目摘要

项目成果

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中文摘要
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英文摘要
DESCRIPTION (Adapted from applicant's abstract): The focus of this proposal is to study the rhodopsin/transducin interface. Synthetic peptides and peptide analogs derived from transducin and rhodopsin will be used as specific ligands for high resolution structural studies (TRNOE and CPMAS NMR) when complexed to their respective partners. By defining the interacting surfaces during photoactivation, an increased understanding of the molecular mechanisms of rhodopsin/transducin complexation is sought. The information derived on the three-dimensional structure of the rhodopsin/transducin complex can assist in devising approaches for treating human diseases (retinitis pigmentosa and night blindness) associated with mutations in rhodopsin.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Rhodopsin-transducin interface: studies with conformationally constrained peptides.
视紫红质-转导蛋白界面:构象受限肽的研究。
DOI: 10.1016/s0006-3495(01)75962-0
发表时间: 2001
期刊: Biophysical journal
影响因子: 3.4
作者: [Arimoto,R, Kisselev,OG, Makara,GM, Marshall,GR]
通讯作者: Marshall,GR
DISCOVERY OF NEW THERAPEUTICS FOR DRUG-FREE REMISSION OF HIV
  • 批准号:
    8652488
  • 项目类别:
  • 资助金额:
    $39.86万
  • 财政年份:
    2013
  • 负责人:
    Garland Ross Marshall
  • 依托单位:
DISCOVERY OF NEW THERAPEUTICS FOR DRUG-FREE REMISSION OF HIV
  • 批准号:
    8915329
  • 项目类别:
  • 资助金额:
    $5.0万
  • 财政年份:
    2013
  • 负责人:
    Garland Ross Marshall
  • 依托单位:
DISCOVERY OF NEW THERAPEUTICS FOR DRUG-FREE REMISSION OF HIV
  • 批准号:
    8838828
  • 项目类别:
  • 资助金额:
    $31.5万
  • 财政年份:
    2013
  • 负责人:
    Garland Ross Marshall
  • 依托单位:
DISCOVERY OF NEW THERAPEUTICS FOR DRUG-FREE REMISSION OF HIV
  • 批准号:
    9058087
  • 项目类别:
  • 资助金额:
    $31.5万
  • 财政年份:
    2013
  • 负责人:
    Garland Ross Marshall
  • 依托单位:
海外基金