MODULATION OF CONTRACTILE FUNCTION IN THE IMMATURE HEART

未成熟心脏收缩功能的调节

• 批准号: 6294534
• 负责人: Michael Artman
• 金额: $ 37.13万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-21 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6294534
• 关键词: action potentials; adenosine; adrenergic agents; age difference; antiarrhythmic agent; calcium ion; calcium metabolism; cardiac myocytes; clinical research; drug interactions; electrophysiology; embryo /fetus cell /tissue; heart contraction; heart pharmacology; human subject; immature animal; laboratory rabbit; membrane transport proteins; neurotransmitter agonist; sarcolemma; sodium ion

DESCRIPTION: (Adapted from the applicant's Description) Recent advances in +___________ our understanding of the fundamental processes involved in calcium regulation in the immature heart now provide the opportunity to develop rational, age-appropriate pharmacological strategies for altering cardiac performance. Studies from the investigator's laboratory have established that the primary calcium transport pathway in the late fetal and early newborn heart is the sarcolemmal sodium-calcium exchanger (NCX). The objective of this application is to exploit the predominant role of NCX as the primary target, either directly or indirectly, for modulation of contractile function in the immature heart. This represents an entirely new approach to the pharmacological manipulation of cardiac contractility during development. Experiments will be performed in freshly isolated ventricular myocytes at four different stages of development in rabbits. The investigator will also study ventricular myocytes isolated from human hearts in order to define critical aspects of regulation of contractile function during human maturation.

描述：（改编自申请人的描述） +___________ 我们对钙调节的基本过程的理解 在不成熟的心脏现在提供机会，发展理性， 改变心脏功能的年龄适当的药理学策略。 研究者实验室的研究已经确定， 晚期胎儿和早期新生儿心脏的钙转运途径是 肌膜钠钙交换器（NCX）。 本申请的目的 是利用NCX作为主要目标的主导作用， 直接或间接地，用于调节未成熟的 心 这代表了一种全新的药理学方法 在发育过程中控制心脏收缩力。 实验将 在四个不同阶段的新鲜分离的心室肌细胞中进行， 兔子的发展 研究者还将研究心室肌细胞 从人的心脏中分离出来，以确定调节的关键方面， 在人类成熟过程中的收缩功能。