STATISTICAL METHODS IN AIDS RESEARCH
艾滋病研究中的统计方法
基本信息
- 批准号:6182998
- 负责人:
- 金额:$ 31.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-08-01 至 2002-05-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS AIDS education /prevention AIDS therapy Africa Caribbean islands India clinical research communicable disease control data collection methodology /evaluation disease /disorder proneness /risk epidemiology high risk behavior /lifestyle human data human therapy evaluation hypodermic needle method development needle sharing relapse /recurrence statistics /biometry vertical transmission virus load
项目摘要
DESCRIPTION (The applicant's abstract) The overall objective of this grant is
to develop and apply statistical methods in AIDS research. The focus is on the
development of statistical methods for the analysis of longitudinal studies of
HIV disease to improve scientific inferences from studies of HIV epidemiology,
prevention and treatment.
There are three specific aims of this proposal. The first specific aim is the
development of methods for the analysis of data that are subject to informative
censoring or more generally informative stochastic coarsening in longitudinal
studies of HIV disease with time to event data. Right censored, interval
censored and current status data are all examples of coarsened time to event
data. This work will have applicability to studies of HIV prevention, treatment
and epidemiology for estimation of HIV incidence rates, relative risks, vaccine
and treatment efficacy. The work under specific aim 1 will be applied to a
study of high risk HIV-negative individuals attending STD clinics in India,
needle exchange evaluations in Baltimore, and a cohort of IV drug users in the
U.S. (ALIVE). The second specific aim is the development of statistical methods
for studies of maternal-infant transmission. This work will include regression
models to estimate maternal-infant transmission rates that adequately account
for loss to follow-up and differential infant mortality, as well as
longitudinal data methods for tracking viral loads in maternal sera and breast
milk and for correlating these loads with risks of maternal-infant
transmission. The work under specific aim 2 will be applied to studies in Haiti
and Zimbabwe. The third specific aim concerns the development of statistical
methods for the analysis of recurrent events such as repeat hospitalizations
and infections. The work under specific aim 3 will entail the development of
one-sample and regression models for recurrent event data that address the
issue of informative censoring for estimation of the occurrence rate of
recurrent events over time and regression models. The methods will be applied
to the ALIVE study.
描述(申请人摘要)本基金的总体目标是
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RONALD S BROOKMEYER其他文献
RONALD S BROOKMEYER的其他文献
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{{ truncateString('RONALD S BROOKMEYER', 18)}}的其他基金
Alzheimer's Disease Risks and Projections Using Multi-State Models with Biomarkers
使用具有生物标志物的多状态模型进行阿尔茨海默病风险和预测
- 批准号:
9447097 - 财政年份:2017
- 资助金额:
$ 31.91万 - 项目类别:
Alzheimer's Disease Risks and Projections Using Multi-State Models with Biomarkers
使用具有生物标志物的多状态模型进行阿尔茨海默病风险和预测
- 批准号:
9274006 - 财政年份:2017
- 资助金额:
$ 31.91万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8698707 - 财政年份:2011
- 资助金额:
$ 31.91万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8507141 - 财政年份:2011
- 资助金额:
$ 31.91万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8308364 - 财政年份:2011
- 资助金额:
$ 31.91万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8209763 - 财政年份:2011
- 资助金额:
$ 31.91万 - 项目类别:
Statistical Methods for Partially Controlled Studies
部分对照研究的统计方法
- 批准号:
6623250 - 财政年份:2002
- 资助金额:
$ 31.91万 - 项目类别:
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Creating Culturally Relevant HIV/ AIDS Education, Prevention & Treatment for Canadian Inuit
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Operating Grants