STATISTICAL METHODS IN AIDS RESEARCH

艾滋病研究中的统计方法

• 批准号: 6388175
• 负责人: RONALD S BROOKMEYER
• 金额: $ 32.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6388175
• 关键词: AIDS; AIDS education /prevention; AIDS therapy; Africa; Caribbean islands; India; clinical research; communicable disease control; data collection methodology /evaluation; disease /disorder proneness /risk; epidemiology; high risk behavior /lifestyle; human data; human therapy evaluation; hypodermic needle; method development; needle sharing; relapse /recurrence; statistics /biometry; vertical transmission; virus load

DESCRIPTION (The applicant's abstract) The overall objective of this grant is to develop and apply statistical methods in AIDS research. The focus is on the development of statistical methods for the analysis of longitudinal studies of HIV disease to improve scientific inferences from studies of HIV epidemiology, prevention and treatment. There are three specific aims of this proposal. The first specific aim is the development of methods for the analysis of data that are subject to informative censoring or more generally informative stochastic coarsening in longitudinal studies of HIV disease with time to event data. Right censored, interval censored and current status data are all examples of coarsened time to event data. This work will have applicability to studies of HIV prevention, treatment and epidemiology for estimation of HIV incidence rates, relative risks, vaccine and treatment efficacy. The work under specific aim 1 will be applied to a study of high risk HIV-negative individuals attending STD clinics in India, needle exchange evaluations in Baltimore, and a cohort of IV drug users in the U.S. (ALIVE). The second specific aim is the development of statistical methods for studies of maternal-infant transmission. This work will include regression models to estimate maternal-infant transmission rates that adequately account for loss to follow-up and differential infant mortality, as well as longitudinal data methods for tracking viral loads in maternal sera and breast milk and for correlating these loads with risks of maternal-infant transmission. The work under specific aim 2 will be applied to studies in Haiti and Zimbabwe. The third specific aim concerns the development of statistical methods for the analysis of recurrent events such as repeat hospitalizations and infections. The work under specific aim 3 will entail the development of one-sample and regression models for recurrent event data that address the issue of informative censoring for estimation of the occurrence rate of recurrent events over time and regression models. The methods will be applied to the ALIVE study.

描述（申请人的摘要）本补助金的总体目标是 在艾滋病研究中开发和应用统计方法。重点是 发展统计方法，用于分析 改善艾滋病毒流行病学研究的科学推论， 预防和治疗。 这项建议有三个具体目标。第一个具体目标是 制定分析数据的方法， 纵向截尾或更一般的信息随机粗化 HIV疾病的研究与事件发生时间数据。右删失，区间 删失数据和当前状态数据都是粗化事件时间的示例 数据这项工作将适用于艾滋病预防、治疗和预防的研究。 艾滋病发病率、相对危险度、疫苗接种、 和治疗效果。具体目标1下的工作将适用于 对印度性病诊所就诊的艾滋病毒阴性高危人群的研究， 巴尔的摩的针头交换评估，以及 美国（活着）。第二个具体目标是发展统计方法 用于研究母婴传播。这项工作将包括回归 估计母婴传播率的模型， 对失访和不同婴儿死亡率的补偿，以及 追踪母体血清和乳腺中病毒载量的纵向数据方法 并将这些负荷与母婴风险相关联 传输具体目标2下的工作将适用于在海地的研究 津巴布韦。第三个具体目标是发展统计 分析复发事件（如重复住院）的方法 和感染具体目标3下的工作将需要制定 针对复发事件数据的单样本和回归模型， 估计发生率的信息截尾问题 随时间推移的复发事件和回归模型。这些方法将应用于 关于ALIVE研究

项目成果

Estimation of HIV incidence in the United States.

• DOI: 10.1001/jama.300.5.520
• 发表时间: 2008-08-06
• 期刊: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
• 影响因子: 120.7
• 作者: Hall, H. Irene;Song, Ruiguang;Rhodes, Philip;Prejean, Joseph;An, Qian;Lee, Lisa M.;Karon, John;Brookmeyer, Ron;Kaplan, Edward H.;McKenna, Matthew T.;Janssen, Robert S.
• 通讯作者: Janssen, Robert S.

Confidence intervals for seasonal relative risk with null boundary values.

具有零边界值的季节性相对风险的置信区间。

• DOI: 10.1097/00001648-200211000-00022
• 发表时间: 2002
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Frangakis,ConstantineE;Varadhan,Ravi
• 通讯作者: Varadhan,Ravi

Covariate-based constrained randomization of group-randomized trials.

• DOI: 10.1191/1740774504cn024oa
• 发表时间: 2004-01-01
• 期刊: Clinical trials (London, England)
• 作者: Moulton, Lawrence H