Statistical Methods for Partially Controlled Studies
部分对照研究的统计方法
基本信息
- 批准号:6623250
- 负责人:
- 金额:$ 24.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-05-01 至 2006-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The objective of this project is to
develop new statistical designs and methods to better evaluate partially
controlled studies in public health.
There are three specific aims. The first aim is to develop methods to evaluate
treatments in studies that: do not directly control which subjects get which
treatment, or which subjects provide outcomes; but do control the location of
the sites that provide the treatments. Because existing methods, including
standard instrumental variables, cannot handle the coexistence of the
uncontrolled factors of taking treatment and of providing outcomes, the work
under aim 1 is essential for proper treatment evaluation. This work will be
applied to ongoing needle exchange programs in Baltimore, for preventing HIV
transmission. The second aim is to develop new methods for clinical trials
where treatment received is controlled, and outcomes are measured; a
post-treatment surrogate endpoint is measured; and the goal is to estimate the
treatments effects on the outcome that are concurrent and not concurrent with
the surrogate. The methods under aim 2 use a new type of stratification for the
uncontrolled surrogates that avoid the complications of standard
stratifications on post-treatment variables. This work is essential for proper
evaluation of early post-treatment symptoms as measures of later treatment
effect, and we will apply it to cancer and ophthalmology trials. The third aim
is to develop methods for study designs where: some persons drop out of a
longitudinal follow-up, and where we can find (double-sample) a representative
subset of the dropouts. This work is essential for preserving generalizability
of results from long follow-up studies, and we will apply it to better evaluate
time to potential drug dependence in youths.
描述(由申请人提供):本项目的目标是
开发新的统计设计和方法,以更好地进行部分评估
公共卫生方面的对照研究。
有三个具体目标。第一个目标是开发评估方法
研究中的处理:不直接控制哪些受试者得到哪些
治疗,或哪些受试者提供结果;但确实控制了
提供治疗的地点。因为现有的方法,包括
标准工具变量,不能处理
接受治疗和提供结果的不可控因素,工作
根据目标1,对于适当的治疗评估是必不可少的。这项工作将是
应用于巴尔的摩正在进行的针头交换计划,以预防艾滋病毒
变速箱。第二个目标是开发临床试验的新方法。
控制接受的治疗,并衡量结果;a
测量治疗后替代终点;目标是估计
治疗对结果的影响是同时发生的和不是同时发生的
代孕妈妈。目标2下的方法使用了一种新类型的分层
不受控制的代理,避免了标准的复杂情况
治疗后变量的分层。这项工作对适当的
评估治疗后早期症状作为后期治疗的措施
效果,我们将把它应用于癌症和眼科试验。第三个目标
是开发研究设计的方法,其中:一些人退出了一项
纵向跟踪,以及我们在哪里可以找到(双样本)代表
辍学学生的子集。这项工作对于保持概括性是必不可少的
长期跟踪研究的结果,我们将应用它来更好地评估
青少年潜在的药物依赖时间到了。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RONALD S BROOKMEYER其他文献
RONALD S BROOKMEYER的其他文献
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{{ truncateString('RONALD S BROOKMEYER', 18)}}的其他基金
Alzheimer's Disease Risks and Projections Using Multi-State Models with Biomarkers
使用具有生物标志物的多状态模型进行阿尔茨海默病风险和预测
- 批准号:
9447097 - 财政年份:2017
- 资助金额:
$ 24.03万 - 项目类别:
Alzheimer's Disease Risks and Projections Using Multi-State Models with Biomarkers
使用具有生物标志物的多状态模型进行阿尔茨海默病风险和预测
- 批准号:
9274006 - 财政年份:2017
- 资助金额:
$ 24.03万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8698707 - 财政年份:2011
- 资助金额:
$ 24.03万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8308364 - 财政年份:2011
- 资助金额:
$ 24.03万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8507141 - 财政年份:2011
- 资助金额:
$ 24.03万 - 项目类别:
Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
横断面艾滋病毒发病率测定的实验室和统计发展
- 批准号:
8209763 - 财政年份:2011
- 资助金额:
$ 24.03万 - 项目类别:
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