OPTIMIZED COIL ARRAYS FOR FUNCTIONAL MRI OF THE BRAIN

用于大脑功能 MRI 的优化线圈阵列

• 批准号: 6074962
• 负责人: George R Duensing
• 金额: $ 51.6万
• 依托单位: INVIVO CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6074962
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; functional magnetic resonance imaging; human subject; phantom model; sound frequency

Functional magnetic resonance imaging (FMRI) has recently shown potential for allowing nearly real time observation of the working human cortex in a non-invasive manner. Applications for FMRI include research (cognitive neuroscience) and clinical (seizure focus identification). Conventional head and surface coils have resulted in limited signal-to- noise ratios (SNR's) and image distortions due to patient motion have limited the reliability of the technique. The phased array coils proposed here utilize advanced multichannel hardware available on major manufacturer's MRI systems to simultaneously increase SNR and provide coverage of the complete cortex with enhancement in selectable regions. An increase in SNR by a factor of at least 2 is expected for major regions of the cortex. An increase in SNR of at least 15% is expected over the entire brain. An integrated mechanical stabilization system will assure less than +/- 1 mm motion in all three axes to minimize motion artifacts. The completion of phase II will provide a complete optimized FMRI array system on the major phased array MRI systems. This system will combine high SNR, minimal motion artifact, comfort and safety with compatible visual, auditory and tactile stimulation accessory devices. The high level of interest in FMRI should result in 100+ unit sales, generating several million dollars of revenue over two to three years. PROPOSED COMMERCIAL APPLICATION: The development of a high performance fiinctional MRI coil array system is expected to generate sales from 8% of the 4,000+ US clinical MRI systems. At a nominal cost $40,000 per device, the 300+ sales represent a $12M market. As functional MRI of the brain gains popularity, this figure could increase by a factor of two or three. The head coil array alone could represent an additional $50M+ in sales, as a replacement for inferior existing clinical head coils.

功能磁共振成像(FMRI)最近显示出了以非侵入性方式近乎实时地观察人类大脑皮质的潜力。功能磁共振成像的应用包括研究(认知神经科学)和临床(癫痫灶识别)。传统的头部和表面线圈导致信噪比(SNR)有限，患者运动造成的图像失真限制了该技术的可靠性。这里提出的相控阵线圈利用主要制造商的MRI系统上提供的先进多通道硬件，同时提高信噪比，并在可选择的区域提供增强的完整皮质覆盖。对于大脑皮层的主要区域，信噪比预计至少会增加2倍。预计整个大脑的信噪比至少会增加15%。集成的机械稳定系统将确保在所有三个轴上的运动小于+/-1 mm，以最大限度地减少运动伪影。第二阶段的完成将为主要的相控阵磁共振成像系统提供一个完整的优化的功能磁共振成像阵列系统。该系统将高信噪比、最小运动伪影、舒适性和安全性与兼容的视觉、听觉和触觉刺激辅助设备结合在一起。人们对功能磁共振成像的高度兴趣应该会带来100+台的销售，在两到三年内创造数百万美元的收入。拟议的商业应用：高性能功能性磁共振线圈阵列系统的开发预计将在美国4,000多个临床磁共振系统中产生8%的销售额。以每台设备4万美元的名义成本计算，300多台手机的销售额相当于1200万美元的市场。随着大脑功能核磁共振的普及，这个数字可能会增加两三倍。仅头部线圈阵列一项就可能带来5000多万美元的额外销售额，以取代劣质的现有临床头部线圈。