OPTIMIZED COIL ARRAYS FOR FUNCTIONAL MRI OF THE BRAIN

用于大脑功能 MRI 的优化线圈阵列

• 批准号: 2040225
• 负责人: George R Duensing
• 金额: $ 9.75万
• 依托单位: INVIVO CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2040225
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; functional magnetic resonance imaging; phantom model; sound frequency

Functional magnetic resonance imaging (FMRI) has recently shown potential for allowing nearly real time observation of the working human cortex in a non-invasive manner. Applications for FMRI include research (cognitive neuroscience) and clinical (seizure focus identification). Conventional head and surface coils have resulted in limited signal-to-noise ratios (SNR's) and image distortions due to patient motion have limited the reliability of the technique. The phased array coils proposed here utilize advanced multichannel hardware available on major manufacturer's MRI systems, to simultaneously increase SNR and provide coverage of the complete cortex with enhancement in selectable regions. An increase in SNR by a factor of at least 3 is expected for major regions of the cortex. An integrated mechanical stabilization system will assure less than +/- 1mm motion in all three axes to minimize motion artifacts. The completion of phase II will provide a complete optimized FMRI array system on the major phased array MRI systems. This system will combine high SNR, minimal motion artifact, comfort and safety with compatible visual, auditory and tactile stimulation accessory devices. The high level of interest in FMRI should result in 100+ unit sales, generating several million dollars of revenue over two to three years. PROPOSED COMMERCIAL APPLICATION: The development of a high performance functional MRI coil array system is expected to generate sales from 8% of the 4,000 US clinical MRI systems. At a nominal cost $35,000 per device, the 300+ sales represent a $10.5M market. As functional MRI of the brain gains popularity, this figure could increase by a factor of two or three. The head coil array alone could represent an additional $5OM in sales, as a replacement for inferior existing clinical head coils.

功能性磁共振成像（FMRI）最近显示出潜力 用于允许对工作的人类皮层进行接近真实的时间观察， 非侵入性的方式。功能磁共振成像的应用包括研究（认知 神经科学）和临床（癫痫病灶识别）。常规 头部和表面线圈导致有限的信噪比 (SNR的）和由于患者运动引起的图像失真限制了 技术的可靠性。这里提出的相控阵列线圈利用 主要制造商的MRI上提供先进的多通道硬件 系统，同时提高信噪比并提供覆盖范围 完整皮质，可选区域增强。增加SNR 对于皮质的主要区域，预期至少为3倍。一个 集成的机械稳定系统将确保小于+/-1 mm 所有三个轴上的运动，以最小化运动伪影。 第二阶段的完成将提供一个完整的优化功能磁共振阵列 主要的相控阵MRI系统。该系统将联合收割机 高信噪比、最小运动伪影、舒适性和安全性， 视觉、听觉和触觉刺激辅助装置。高电平 对功能磁共振成像感兴趣的人应该会带来100多台的销售， 在两到三年的时间里创造了100万美元的收入。 拟定商业应用： 研制了一种高性能的功能磁共振成像线圈阵列系统， 预计将从美国4,000台临床MRI系统中的8%产生销售额。 每台设备的名义成本为35，000美元，300多台设备的销售额为1050万美元， 市场随着大脑功能性核磁共振成像的普及，这一数字可能 增加了两到三倍。头部线圈阵列本身可以 代表额外的500万美元的销售额，作为对劣质产品的替代， 现有的临床头部线圈。