OPTIMIZED COIL ARRAYS FOR FUNCTIONAL MRI OF THE BRAIN

用于大脑功能 MRI 的优化线圈阵列

• 批准号: 6394641
• 负责人: George R Duensing
• 金额: $ 18.04万
• 依托单位: INVIVO CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394641
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; functional magnetic resonance imaging; human subject; phantom model; sound frequency

Functional magnetic resonance imaging (FMRI) has recently shown potential for allowing nearly real time observation of the working human cortex in a non-invasive manner. Applications for FMRI include research (cognitive neuroscience) and clinical (seizure focus identification). Conventional head and surface coils have resulted in limited signal-to- noise ratios (SNR's) and image distortions due to patient motion have limited the reliability of the technique. The phased array coils proposed here utilize advanced multichannel hardware available on major manufacturer's MRI systems to simultaneously increase SNR and provide coverage of the complete cortex with enhancement in selectable regions. An increase in SNR by a factor of at least 2 is expected for major regions of the cortex. An increase in SNR of at least 15% is expected over the entire brain. An integrated mechanical stabilization system will assure less than +/- 1 mm motion in all three axes to minimize motion artifacts. The completion of phase II will provide a complete optimized FMRI array system on the major phased array MRI systems. This system will combine high SNR, minimal motion artifact, comfort and safety with compatible visual, auditory and tactile stimulation accessory devices. The high level of interest in FMRI should result in 100+ unit sales, generating several million dollars of revenue over two to three years. PROPOSED COMMERCIAL APPLICATION: The development of a high performance fiinctional MRI coil array system is expected to generate sales from 8% of the 4,000+ US clinical MRI systems. At a nominal cost $40,000 per device, the 300+ sales represent a $12M market. As functional MRI of the brain gains popularity, this figure could increase by a factor of two or three. The head coil array alone could represent an additional $50M+ in sales, as a replacement for inferior existing clinical head coils.

功能性磁共振成像（FMRI）最近显示出以非侵入性方式近乎实时观察工作中的人类皮层的潜力。 FMRI 的应用包括研究（认知神经科学）和临床（癫痫病灶识别）。传统的头部和表面线圈导致信噪比（SNR）有限，并且由于患者运动导致的图像失真限制了该技术的可靠性。这里提出的相控阵线圈利用主要制造商的 MRI 系统上可用的先进多通道硬件来同时提高 SNR 并提供对整个皮层的覆盖，并在可选区域中进行增强。皮质主要区域的 SNR 预计将增加至少 2 倍。整个大脑的 SNR 预计将增加至少 15%。集成机械稳定系统将确保所有三个轴的运动小于 +/- 1 毫米，以最大限度地减少运动伪影。第二阶段的完成将为主要相控阵MRI系统提供完整优化的FMRI阵列系统。该系统将高信噪比、最小的运动伪影、舒适性和安全性与兼容的视觉、听觉和触觉刺激辅助设备结合在一起。对 FMRI 的高度兴趣应该会导致 100 多个单位的销售，在两到三年内产生数百万美元的收入。拟议的商业应用：高性能功能 MRI 线圈阵列系统的开发预计将为美国 4,000 多个临床 MRI 系统中的 8% 带来销售额。每台设备的名义成本为 40,000 美元，超过 300 台的销量相当于 1200 万美元的市场。随着大脑功能性核磁共振成像的普及，这个数字可能会增加两到三倍。作为现有劣质临床头部线圈的替代品，仅头部线圈阵列就可以带来 5000 万美元以上的额外销售额。