BARBADOS INCIDENCE STUDY OF EYE DISEASES II

巴巴多斯眼病发病率研究 II

• 批准号: 6178977
• 负责人: MCRISTINA LESKE
• 金额: $ 110.39万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6178977
• 关键词: African Caribbean; aging; alcoholism /alcohol abuse; blindness; cardiovascular disorder; cataract; clinical research; cooperative study; diabetes mellitus; diabetic retinopathy; dietary supplements; disease /disorder etiology; disease /disorder proneness /risk; epidemiology; eye disorder diagnosis; eye fundus photography; eye refractometry; family genetics; gene environment interaction; glaucoma; glaucoma test; human middle age (35-64); human old age (65+); human population study; human subject; hypertension; interview; longitudinal human study; macular degeneration; nutrition related tag; pathologic process; statistics /biometry; tobacco abuse; vision tests; visual fields; visual perception

The proposed Barbados Incidence Study of Eye Diseases II (BISED II) aims to collect 9-year incidence and progression data on open-angle glaucoma (OAG) and age-related cataract in the predominantly black population of Barbados, West Indies, as well as to obtain natural history data on age- related macular changes and diabetic changes. OAG and cataract are the two major causes of blindness in populations of African origin, accounting for about half of visual loss. Despite their high prevalence and public health importance, data on blacks are limited and no clear explanation for the increased risk exists. Early macular changes were frequent in the BES. Although diabetic retinopathy was less common, about one-fifth of the population has diabetes, thus raising questions about risk factors for DR in a black population. BISED II provides a unique opportunity to obtain the first long term incidence and progression data on a large population- based cohort, as such longitudinal data are not available for black populations. BISED II will provide new information concerning natural history and underlying factors for these chronic, life-long eye diseases, to assist in understanding etiology, identifying groups at high risk, and developing strategies to control visual loss. A shorter follow-up is insufficient to provide this information. To achieve these aims, BISED II will re-examine the surviving cohort of the Barbados Eye Study (BES). The BES was conducted from 1988 to 1992 to measure prevalence and risk factors for OAG, cataract, age-related macular degeneration and diabetic retinopathy, while providing baseline data for further incidence measurements. The BES was followed by the Barbados Incidence Study of Eye Diseases (BISED; 1992-1997), which is determining 4-year incidence and progression for these conditions. High participation rates of 84% and 85% were achieved by BES and BISED, respectively, among the eligible cohort. The positive response of the cohort and the past experience gained in conducting BES and BISED enhance the feasibility of successful follow-up. Given the cohort size, follow-up rates of incidence and progression can be estimated with high precision. Given the high prevalence and incidence, a wide range of relative risks can be detected. In summary, the BES cohort is a unique resource to study the major causes of blindness and provides an opportunity to learn, for the first time, about their long-term patterns of occurrence in a black population. This information may assist to address major racial differences in prevalence and has important public health implications.

巴巴多斯眼病发病率研究II（BISED II）旨在 收集9年开角型青光眼的发病率和进展数据 (OAG)和年龄相关性白内障的主要黑人人口， 巴巴多斯，西印度群岛，以及获得自然历史数据的年龄- 相关的黄斑改变和糖尿病改变。OAG和白内障是 非洲裔人口失明的主要原因，占 大约一半的视力丧失。尽管其流行率和公共卫生 重要的是，关于黑人的数据是有限的，没有明确的解释， 风险增加。早期黄斑改变在BES中是常见的。 虽然糖尿病视网膜病变不太常见，但大约五分之一的人 人群患有糖尿病，因此提出了有关DR风险因素的问题 在黑人人口中。BISED II提供了一个独特的机会， 第一个大规模人群的长期发病率和进展数据- 基于队列，因为黑人没有此类纵向数据 人口。BISED II将提供有关自然 这些慢性、终身性眼病的病史和潜在因素， 帮助了解病因，识别高危人群， 制定控制视力丧失的策略。更短的后续行动是 不足以提供这些信息。为了实现这些目标，BISED II 将重新检查巴巴多斯眼科研究（BES）的存活队列。的 BES于1988年至1992年进行，以测量患病率和风险因素 用于OAG、白内障、年龄相关性黄斑变性和糖尿病 视网膜病变，同时为进一步的发病率提供基线数据 测量. BES之后是巴巴多斯眼发病率研究 疾病（BISED; 1992-1997年），它确定4年发病率， 这些条件的进展。84%和85%的高参与率 分别由BES和BISED在合格队列中实现。 该群体的积极反应和过去在 开展BES和BISED提高了成功后续行动的可行性。 考虑到队列规模，随访的发病率和进展率可以 高精度的估计。鉴于高流行率和高发病率， 可以检测到各种各样的相对风险。总之，BES队列 是研究失明主要原因的独特资源， 第一次有机会了解他们的长期 发生在黑人群体中的模式。这些信息可能有助于 解决流行率的主要种族差异，并具有重要的公众 健康影响。