A genome-wide search for genes underlying the developmental origins of health and disease

全基因组搜索健康和疾病发育起源的基因

• 批准号: nhmrc : 572613
• 负责人: A/Pr Craig Pennell
• 金额: $ 68.18万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genome-wide-search-health-disease/101074
• 关键词: genome; wide; search; genes; underlying

Epidemic rises in the incidence of many chronic diseases such as obesity, type 2 diabetes, hypertension, coronary artery disease and mental illness have occurred in Australia over the last two decades. Antenatal, early life and childhood factors have been consistently associated with the development of such diseases. We propose to conduct a genome-wide scan in an exceptional longitudinal birth cohort in order to identify the genetic mechanisms linking early life event and adult disease.

在过去二十年中，澳大利亚的许多慢性疾病，如肥胖症、2型糖尿病、高血压、冠状动脉疾病和精神疾病的发病率普遍上升。产前、生命早期和儿童时期的因素一直与这些疾病的发生有关。我们建议在一个特殊的纵向出生队列中进行全基因组扫描，以确定将早期生活事件和成年疾病联系起来的遗传机制。