BAYLOR BIRCWH PROGRAM

贝勒妇女健康中心的使命是通过发展和支持妇女健康学者，为他们提供各种跨学科主题、科学学科和方法方面的指导和培训，从而增加妇女健康研究。所有奖学金获得者将接受国家公认的领导人的密集指导。为了寻找、招募和培训致力于妇女健康的学者，我们设想一种合作安排，不仅涉及传统上提供大部分妇女保健服务的部门(内科、产科和妇科)，还包括其他学科-康复、伦理学、分子医学、卫生服务研究。一个强大的咨询委员会包括分子/临床研究(P.I.Joe；Leigh Simpson、Arthur Beaudet、Colin Bishop、Bert O‘Malley、Larry Chan、Huda Zogbhi)以及临床/卫生服务/人口研究(Co.P.I.Nelda Wray、项目主任Jennifer Hays、玛格丽特·诺塞克、Baruch Brody)的专业知识。贝勒已经拥有强大的内部候选人库，我们将积极招募贝勒以外的候选人，特别是少数族裔候选人和残疾候选人。候选人将首先选择一位导师，然后与导师一起准备一份申请书，详细说明以前的研究和教育经验，以及为BIRCWH奖项建议的教育、研究和指导计划。所有申请者将由咨询委员会审查和挑选。IWHR学者可以选择分子/临床途径或临床/卫生服务/人口研究途径，目标是学术独立。所有IWHR学者将被要求参加三门教学课程，内容包括妇女健康问题以及临床研究和学术成功的基础。无论途径如何，学者将根据以前的研究经验进一步分层(轨道1重要，轨道2很少或没有研究经验或培训)。第二轨道临床/卫生服务/人口研究学者将被要求完成适当的硕士课程(例如，M.P.H.)。无论途径或路线，目标是学者在2-3年内提交国家卫生研究院的拨款。各种额外的活动，包括BIRCWH研究会议和BIRCWH杰出演讲者系列，将以持续的方式将BIRCWH的所有学者和导师聚集在一起，利用想法，交叉培养项目，并加强贝勒的妇女健康研究。GRANT-F31AT00064-01拟议工作的长期目标是在植物药物的鉴定和表征、生物测定指导的分离、活性成分的分离和鉴定以及人类使用的提取物的生产方面接受培训。本研究的具体目的是首先采集紫叶Viburnum prunifolium L.的树干树皮样本，利用宏观特征、光学和扫描电子显微镜技术以及随机引发的聚合酶链式反应(AP-PCR)DNA分析对材料进行表征。将生产一种粗制的甲醇提取物，并建立一个高效液相图谱。提取物将接受雌激素受体结合、5-羟色胺受体结合和子宫松弛生物测定。将使用生物测定定向分离来分离活性化合物；将使用高效液相色谱和LC-MS进行后续的结构鉴定。酒精提取物的配方将与有效成分的标准化参数一起使用。这些目标对公共卫生至关重要，有助于建立生产安全、有效、高质量的草本提取物供消费者使用的方法。

The Baylor BIRCWH has as its mission increasing women's health research by developing and supporting women's health Scholars, providing them instruction and training in a variety of interdisciplinary topics, scientific disciplines and methodologies. All Scholars will receive intense mentoring from nationally recognized leaders. In order to identify, recruit and train Scholars with strong commitments to women's health, we envision a collaborative arrangement involving not only the departments that traditionally deliver the greater part of women's healthcare (Medicine, Obstetrics and Gynecology), but other disciplines -Rehabilitation, Ethics, Molecular Medicine, Health Services Research. A strong Advisory Committee includes expertise in both Molecular/Clinical research (P.I. Joe; Leigh Simpson, Arthur Beaudet, Colin Bishop, Bert O'Malley, Larry Chan, Huda Zogbhi) as well as Clinical/Health Services/Population Research (Co. P.I. Nelda Wray, Program Director Jennifer Hays, Margaret Nosek, Baruch Brody). Baylor already has a strong internal pool of candidates, and we will aggressively recruit candidates outside Baylor, especially minority candidates and candidates with disabilities. Candidates will first select a mentor and then with the mentor prepare an application detailing prior research and educational experiences and the proposed educational, research, and mentoring plan for the BIRCWH award. All applicants will be reviewed and selected by the Advisory Committee. IWHR Scholars may select either a Molecular/Clinical pathway or a Clinical/Health Services/Population Research pathway, with the goal of academic independence. All IWHR Scholars will be required to take three didactic courses encompassing women's health issues and the fundamentals of clinical investigation and academic success. Irrespective of pathway, Scholars will be further stratified by prior research experience (Track 1 significant, Track 2 little to no research experience or training). Track 2 Scholars in Clinical/Health Services/Population Research will be required to complete an appropriate Master's program (e.g., M.P.H.). Regardless of pathway or track, the goal is for the Scholar to submit an NIH grant in 2-3 years. A variety of additional activities, including BlRCWH research conferences and a BIRCWH Distinguished Speaker series, will bring all BIRCWH Scholars and mentors together in an ongoing fashion to leverage ideas, cross-fertilize projects, and enhance women's health research at Baylor. GRANT-F31AT00064-01 Long term objectives of the proposed work are to receive training in identification and characterization of botanicals, bioassay guided fractionation, isolation and elucidation of active constituents, and production of extracts for human use. The specific aims are to first collect stem bark samples of Viburnum prunifolium L., characterize the material using macroscopic features, light and scanning electron microscope techniques, and arbitrarily-primed polymerase chain reaction (AP-PCR) DNA analysis. A crude methanol extract will be produced and an HPLC profile established. The extract will be subjected to estrogen receptor binding, serotonin receptor binding, and uterine relaxation bioassays. Bioassay directed fractionation will be used to isolate active compounds; HPLC and LC-MS will be employed for subsequent structure elucidation. An alcoholic extract will be formulated with parameters for standardizing to the active constituent. These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use.