BAYLOR BIRCWH PROGRAM

贝勒BIRCWH的使命是发展和支持妇女健康学者，为她们提供各种跨学科主题、科学学科和方法的指导和培训，从而加强妇女健康研究。所有的学者都将接受来自全国知名领袖的指导。为了确定、招募和培训对妇女健康有坚定承诺的学者，我们设想一种合作安排，不仅涉及传统上提供大部分妇女保健的部门（医学、产科和妇科），还涉及其他学科——康复、伦理学、分子医学、卫生服务研究。一个强大的咨询委员会包括分子/临床研究（P.I. Joe; Leigh Simpson, Arthur Beaudet, Colin Bishop, Bert O'Malley, Larry Chan, Huda Zogbhi）以及临床/健康服务/人口研究（P.I. Nelda Wray，项目主任Jennifer Hays， Margaret Nosek, Baruch Brody）的专业知识。贝勒已经拥有强大的内部候选人库，我们将积极招募贝勒以外的候选人，特别是少数族裔候选人和残疾候选人。候选人将首先选择一位导师，然后与导师一起准备一份申请，详细说明之前的研究和教育经历，以及拟议的BIRCWH奖的教育、研究和指导计划。所有申请人将由咨询委员会审查和选择。IWHR学者可以选择分子/临床途径或临床/卫生服务/人口研究途径，以学术独立为目标。所有妇女健康研究所的学者将被要求学习三门教学课程，内容包括妇女健康问题以及临床调查和学术成功的基础知识。无论途径如何，学者将根据先前的研究经验进一步分层（第一方向重要，第二方向很少或没有研究经验或培训）。临床/卫生服务/人口研究领域的学者需要完成相应的硕士课程（如公共卫生学硕士）。无论途径或轨道，目标是学者在2-3年内提交NIH资助。各种其他活动，包括BlRCWH研究会议和BIRCWH杰出演讲者系列，将使所有BIRCWH学者和导师以一种持续的方式聚集在一起，以利用想法，交叉受精项目，并加强贝勒大学的妇女健康研究。拟议工作的长期目标是接受植物药物鉴定和表征、生物测定指导分离、活性成分分离和阐明以及人用提取物生产方面的培训。具体目的是首先收集Viburnum prunifolium L.茎皮样品，利用宏观特征、光学和扫描电镜技术以及任意引物聚合酶链反应（AP-PCR） DNA分析对材料进行表征。将生产粗甲醇提取物并建立高效液相色谱图谱。提取物将进行雌激素受体结合、血清素受体结合和子宫松弛生物测定。生物测定定向分离将用于分离活性化合物；HPLC和LC-MS将用于后续的结构解析。将配制酒精提取物，并对其活性成分进行标准化。这些目标对公共卫生至关重要，有助于确定安全、有效、优质的草药提取物的生产方法，供消费者使用。

The Baylor BIRCWH has as its mission increasing women's health research by developing and supporting women's health Scholars, providing them instruction and training in a variety of interdisciplinary topics, scientific disciplines and methodologies. All Scholars will receive intense mentoring from nationally recognized leaders. In order to identify, recruit and train Scholars with strong commitments to women's health, we envision a collaborative arrangement involving not only the departments that traditionally deliver the greater part of women's healthcare (Medicine, Obstetrics and Gynecology), but other disciplines -Rehabilitation, Ethics, Molecular Medicine, Health Services Research. A strong Advisory Committee includes expertise in both Molecular/Clinical research (P.I. Joe; Leigh Simpson, Arthur Beaudet, Colin Bishop, Bert O'Malley, Larry Chan, Huda Zogbhi) as well as Clinical/Health Services/Population Research (Co. P.I. Nelda Wray, Program Director Jennifer Hays, Margaret Nosek, Baruch Brody). Baylor already has a strong internal pool of candidates, and we will aggressively recruit candidates outside Baylor, especially minority candidates and candidates with disabilities. Candidates will first select a mentor and then with the mentor prepare an application detailing prior research and educational experiences and the proposed educational, research, and mentoring plan for the BIRCWH award. All applicants will be reviewed and selected by the Advisory Committee. IWHR Scholars may select either a Molecular/Clinical pathway or a Clinical/Health Services/Population Research pathway, with the goal of academic independence. All IWHR Scholars will be required to take three didactic courses encompassing women's health issues and the fundamentals of clinical investigation and academic success. Irrespective of pathway, Scholars will be further stratified by prior research experience (Track 1 significant, Track 2 little to no research experience or training). Track 2 Scholars in Clinical/Health Services/Population Research will be required to complete an appropriate Master's program (e.g., M.P.H.). Regardless of pathway or track, the goal is for the Scholar to submit an NIH grant in 2-3 years. A variety of additional activities, including BlRCWH research conferences and a BIRCWH Distinguished Speaker series, will bring all BIRCWH Scholars and mentors together in an ongoing fashion to leverage ideas, cross-fertilize projects, and enhance women's health research at Baylor. GRANT-F31AT00064-01 Long term objectives of the proposed work are to receive training in identification and characterization of botanicals, bioassay guided fractionation, isolation and elucidation of active constituents, and production of extracts for human use. The specific aims are to first collect stem bark samples of Viburnum prunifolium L., characterize the material using macroscopic features, light and scanning electron microscope techniques, and arbitrarily-primed polymerase chain reaction (AP-PCR) DNA analysis. A crude methanol extract will be produced and an HPLC profile established. The extract will be subjected to estrogen receptor binding, serotonin receptor binding, and uterine relaxation bioassays. Bioassay directed fractionation will be used to isolate active compounds; HPLC and LC-MS will be employed for subsequent structure elucidation. An alcoholic extract will be formulated with parameters for standardizing to the active constituent. These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use.