BAYLOR BIRCWH PROGRAM

贝勒伯克WH计划

• 批准号: 6208550
• 负责人: JOE LEIGH SIMPSON
• 金额: $ 50万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-10 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6208550
• 关键词: clinical research; clinical trials; continuing education; curriculum; female; health care service; health science research; health science research potential; health services research tag; minority health professional; role model; women's health

The Baylor BIRCWH has as its mission increasing women's health research by developing and supporting women's health Scholars, providing them instruction and training in a variety of interdisciplinary topics, scientific disciplines and methodologies. All Scholars will receive intense mentoring from nationally recognized leaders. In order to identify, recruit and train Scholars with strong commitments to women's health, we envision a collaborative arrangement involving not only the departments that traditionally deliver the greater part of women's healthcare (Medicine, Obstetrics and Gynecology), but other disciplines -Rehabilitation, Ethics, Molecular Medicine, Health Services Research. A strong Advisory Committee includes expertise in both Molecular/Clinical research (P.I. Joe; Leigh Simpson, Arthur Beaudet, Colin Bishop, Bert O'Malley, Larry Chan, Huda Zogbhi) as well as Clinical/Health Services/Population Research (Co. P.I. Nelda Wray, Program Director Jennifer Hays, Margaret Nosek, Baruch Brody). Baylor already has a strong internal pool of candidates, and we will aggressively recruit candidates outside Baylor, especially minority candidates and candidates with disabilities. Candidates will first select a mentor and then with the mentor prepare an application detailing prior research and educational experiences and the proposed educational, research, and mentoring plan for the BIRCWH award. All applicants will be reviewed and selected by the Advisory Committee. IWHR Scholars may select either a Molecular/Clinical pathway or a Clinical/Health Services/Population Research pathway, with the goal of academic independence. All IWHR Scholars will be required to take three didactic courses encompassing women's health issues and the fundamentals of clinical investigation and academic success. Irrespective of pathway, Scholars will be further stratified by prior research experience (Track 1 significant, Track 2 little to no research experience or training). Track 2 Scholars in Clinical/Health Services/Population Research will be required to complete an appropriate Master's program (e.g., M.P.H.). Regardless of pathway or track, the goal is for the Scholar to submit an NIH grant in 2-3 years. A variety of additional activities, including BlRCWH research conferences and a BIRCWH Distinguished Speaker series, will bring all BIRCWH Scholars and mentors together in an ongoing fashion to leverage ideas, cross-fertilize projects, and enhance women's health research at Baylor. GRANT-F31AT00064-01 Long term objectives of the proposed work are to receive training in identification and characterization of botanicals, bioassay guided fractionation, isolation and elucidation of active constituents, and production of extracts for human use. The specific aims are to first collect stem bark samples of Viburnum prunifolium L., characterize the material using macroscopic features, light and scanning electron microscope techniques, and arbitrarily-primed polymerase chain reaction (AP-PCR) DNA analysis. A crude methanol extract will be produced and an HPLC profile established. The extract will be subjected to estrogen receptor binding, serotonin receptor binding, and uterine relaxation bioassays. Bioassay directed fractionation will be used to isolate active compounds; HPLC and LC-MS will be employed for subsequent structure elucidation. An alcoholic extract will be formulated with parameters for standardizing to the active constituent. These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use.

贝勒 BIRCWH 的使命是通过培养和支持女性健康学者，为她们提供各种跨学科主题、科学学科和方法的指导和培训，从而增加女性健康研究。 所有学者都将得到国家认可领导人的严格指导。 为了识别、招募和培训对妇女健康做出坚定承诺的学者，我们设想建立一种合作安排，不仅涉及传统上提供大部分妇女医疗保健的部门（医学、妇产科），还涉及其他学科——康复、伦理学、分子医学、卫生服务研究。 强大的咨询委员会包括分子/临床研究（P.I. Joe；Leigh Simpson、Arthur Beaudet、Colin Bishop、Bert O'Malley、Larry Chan、Huda Zogbhi）以及临床/健康服务/人口研究（Co. P.I. Nelda Wray、项目总监 Jennifer Hays、Margaret Nosek、Baruch Brody）方面的专业知识。贝勒已经拥有强大的内部候选人库，我们将积极招募贝勒以外的候选人，特别是少数族裔候选人和残疾候选人。候选人将首先选择一名导师，然后与导师一起准备一份申请，详细说明之前的研究和教育经验以及 BIRCWH 奖拟议的教育、研究和指导计划。所有申请人将由顾问委员会审查和选择。 IWHR 学者可以选择分子/临床途径或临床/健康服务/人口研究途径，以实现学术独立。所有 IWHR 学者都必须参加三门教学课程，内容涵盖妇女健康问题以及临床研究和学术成功的基础知识。无论途径如何，学者都将根据先前的研究经验进一步分层（轨道 1 重要，轨道 2 很少甚至没有研究经验或培训）。临床/健康服务/人口研究领域的第二轨学者将需要完成适当的硕士课程（例如 M.P.H.）。无论途径或途径如何，学者的目标是在 2-3 年内提交 NIH 资助。 各种其他活动，包括 BlRCWH 研究会议和 BIRCWH 杰出演讲者系列，将以持续的方式将所有 BIRCWH 学者和导师聚集在一起，以利用想法、交叉促进项目并加强贝勒的女性健康研究。 GRANT-F31AT00064-01 拟议工作的长期目标是接受植物药的鉴定和表征、生物测定引导的分馏、活性成分的分离和阐明以及人类使用的提取物的生产方面的培训。具体目标是首先收集 Viburnum prunifolium L. 的茎皮样本，利用宏观特征、光学和扫描电子显微镜技术以及任意引发的聚合酶链反应 (AP-PCR) DNA 分析来表征材料。将生产粗甲醇提取物并建立 HPLC 谱。提取物将进行雌激素受体结合、血清素受体结合和子宫松弛生物测定。将使用生物测定定向分级分离来分离活性化合物； HPLC和LC-MS将用于后续结构解析。将使用用于标准化活性成分的参数来配制醇提取物。这些目标对于公共健康至关重要，有助于建立安全、有效、优质的草药提取物的生产方法供消费者使用。