BAYLOR BIRCWH PROGRAM

贝勒伯克WH计划

• 批准号: 6526464
• 负责人: JOE LEIGH SIMPSON
• 金额: $ 50万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-10 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6526464
• 关键词: clinical research; clinical trials; continuing education; curriculum; female; health care service; health science research; health science research potential; health services research tag; minority health professional; role model; women's health

The Baylor BIRCWH has as its mission increasing women's health research by developing and supporting women's health Scholars, providing them instruction and training in a variety of interdisciplinary topics, scientific disciplines and methodologies. All Scholars will receive intense mentoring from nationally recognized leaders. In order to identify, recruit and train Scholars with strong commitments to women's health, we envision a collaborative arrangement involving not only the departments that traditionally deliver the greater part of women's healthcare (Medicine, Obstetrics and Gynecology), but other disciplines -Rehabilitation, Ethics, Molecular Medicine, Health Services Research. A strong Advisory Committee includes expertise in both Molecular/Clinical research (P.I. Joe; Leigh Simpson, Arthur Beaudet, Colin Bishop, Bert O'Malley, Larry Chan, Huda Zogbhi) as well as Clinical/Health Services/Population Research (Co. P.I. Nelda Wray, Program Director Jennifer Hays, Margaret Nosek, Baruch Brody). Baylor already has a strong internal pool of candidates, and we will aggressively recruit candidates outside Baylor, especially minority candidates and candidates with disabilities. Candidates will first select a mentor and then with the mentor prepare an application detailing prior research and educational experiences and the proposed educational, research, and mentoring plan for the BIRCWH award. All applicants will be reviewed and selected by the Advisory Committee. IWHR Scholars may select either a Molecular/Clinical pathway or a Clinical/Health Services/Population Research pathway, with the goal of academic independence. All IWHR Scholars will be required to take three didactic courses encompassing women's health issues and the fundamentals of clinical investigation and academic success. Irrespective of pathway, Scholars will be further stratified by prior research experience (Track 1 significant, Track 2 little to no research experience or training). Track 2 Scholars in Clinical/Health Services/Population Research will be required to complete an appropriate Master's program (e.g., M.P.H.). Regardless of pathway or track, the goal is for the Scholar to submit an NIH grant in 2-3 years. A variety of additional activities, including BlRCWH research conferences and a BIRCWH Distinguished Speaker series, will bring all BIRCWH Scholars and mentors together in an ongoing fashion to leverage ideas, cross-fertilize projects, and enhance women's health research at Baylor. GRANT-F31AT00064-01 Long term objectives of the proposed work are to receive training in identification and characterization of botanicals, bioassay guided fractionation, isolation and elucidation of active constituents, and production of extracts for human use. The specific aims are to first collect stem bark samples of Viburnum prunifolium L., characterize the material using macroscopic features, light and scanning electron microscope techniques, and arbitrarily-primed polymerase chain reaction (AP-PCR) DNA analysis. A crude methanol extract will be produced and an HPLC profile established. The extract will be subjected to estrogen receptor binding, serotonin receptor binding, and uterine relaxation bioassays. Bioassay directed fractionation will be used to isolate active compounds; HPLC and LC-MS will be employed for subsequent structure elucidation. An alcoholic extract will be formulated with parameters for standardizing to the active constituent. These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use.

贝勒市妇女健康研究中心的使命是通过培养和支持妇女健康学者，为她们提供各种跨学科主题、科学学科和方法方面的指导和培训，增加妇女健康研究。 所有的学者都将得到国家认可的领导人的指导。 为了确定，招聘和培训学者与妇女健康的坚定承诺，我们设想一个合作安排，不仅涉及传统上提供妇女的医疗保健（医学，妇产科）的大部分部门，但其他学科-康复，伦理学，分子医学，卫生服务研究。 一个强大的咨询委员会包括分子/临床研究（P.I.乔; Leigh Simpson，亚瑟Beaudet，Colin Bishop，Bert O 'Malley，Larry Chan，Huda Zogbhi）以及临床/健康服务/人口研究（Co. P.I. Nelda Wray，项目总监Jennifer Hays，Margaret Nosek，Baruch Brody）。贝勒已经有了一个强大的内部候选人库，我们将积极招募贝勒以外的候选人，特别是少数族裔候选人和残疾候选人。候选人将首先选择一位导师，然后与导师一起准备一份申请，详细说明先前的研究和教育经验以及BIRCWH奖项的拟议教育，研究和指导计划。所有申请人将由咨询委员会审查和挑选。IWHR学者可以选择分子/临床途径或临床/卫生服务/人口研究途径，以实现学术独立性。所有国际妇女健康研究所的学者都必须参加三门教学课程，包括妇女健康问题和临床研究和学术成功的基础知识。无论途径如何，学者将根据先前的研究经验进一步分层（轨道1显著，轨道2很少或没有研究经验或培训）。轨道2学者在临床/卫生服务/人口研究将被要求完成适当的硕士课程（例如，M.P.H.）。无论途径或轨道，目标是为学者提交NIH补助金在2-3年。 各种额外的活动，包括BlRCWH研究会议和一个BIRCWH杰出演讲者系列，将带来所有BIRCWH学者和导师在一个持续的时尚，以利用思想，交叉施肥项目，并加强妇女的健康研究在贝勒。GRANT-F31 AT 00064 -01拟议工作的长期目标是接受植物药鉴定和表征、生物测定指导的分馏、活性成分的分离和阐明以及人用提取物生产方面的培训。具体目的是首先采集桃叶荚树的茎皮样品，使用宏观特征、光学和扫描电子显微镜技术以及任意引物聚合酶链反应（AP-PCR）DNA分析对材料进行表征。将生产粗甲醇提取物并建立HPLC图谱。将对浸提液进行雌激素受体结合、5-羟色胺受体结合和子宫舒张生物测定。将使用生物测定定向分馏分离活性化合物;将使用HPLC和LC-MS进行后续结构解析。醇提取物将与活性成分标准化的参数一起配制。这些目标对公共健康至关重要，有助于建立生产安全，有效，优质草药提取物供消费者使用的方法。