NEUROBIOLOGICAL ASPECTS OF AGING

这个有指导的临床科学家发展计划的目的是支持在与衰老相关的神经科学学科中优秀的医生实习生的职业发展，从而导致研究独立。培训将作为一项联合计划进行，利用当地神经科学界的各种和广泛的资源，包括加州大学圣地亚哥分校、斯克里普斯研究基金会、索尔克研究所和伯纳姆基金会。该项目的优秀申请者将在当地和加州大学圣迭戈分校神经科学系临床神经学项目和全国神经学培训项目的应届毕业生中招聘。要求每年提供2个职位，为期5年，共计培训职位。该项目将由神经科学部管理，这是一个联合的基础科学临床部门。该学院在遗传、分子、细胞系统、神经系统和衰老研究的行为和建模方面拥有相当强的实力。该培训计划将为受聘者提供三种类型的学术经验，以引导研究独立。1)基础神经科学培训，通过正式的神经科学研究生院课程工作和实验室研究轮换完成，2)3-4年的强化指导研究，以及3)连续的研讨会、老龄课程和讲座。拥有博士学位的实习生将有机会参加加州大学圣迭戈分校的神经科学研究生项目，并提前获得神经科学博士学位。该培训计划旨在让学员接触到一系列神经科学主题，这些主题需要从全面和学术的角度来处理与衰老相关的问题，从基因表达的研究到整个系统/行为方法。然后，个别受训者将选择一个学科作为重点，并培养一个职业研究主题。

The purpose of this Mentored Clinical Scientist Development Program is to support the career development of outstanding physician trainees in an aging-related neuroscience discipline, leading to research independence. Training will be conducted as a joint program taking advantage of the diverse and extensive resource of the local neuroscience community, including the University of California-San Diego, Scripps Research Foundation, the Salk Institute, and the Burnham Foundation. Outstanding applicants for the program will be recruited both locally and graduating residents of the clinical neurology program in the Department of Neurosciences at UCSD, and from neurology training programs nationally. 2 slots per year are requested for a 5 year period, totaling training positions. The program will be administered by the Department of Neurosciences, a joint basic science clinical department. The faculty possesses considerable strength in the genetic, molecular, cellular systems, behavioral and modeling aspects of nervous system and aging research. The training program will provide appointees three types of academic experiences to lead to research independence. 1) Basic neuroscience training, accomplished by formal Neuroscience Graduate Program course work and laboratory research rotations, 2) a 3-4 year period of intensive mentored research, and 3) a continuous curriculum of symposia, coursework in aging, and lectures. Trainees who do have a Ph.D. degree will have the opportunity to enroll in the UCSD Neuroscience Graduate Program and early a Neuroscience doctoral degree. The training program intends to expose the trainees to a breath of neuroscience topics that are required to approach aging-related questions from a comprehensive and scholarly vantage point, ranging from the study of gene expression to whole systems/behavioral approaches. Individual trainees will then choose a discipline within which to focus and foster a career research topic.