NEUROBIOLOGICAL ASPECTS OF AGING

该临床科学家指导发展计划的目的是支持在与衰老相关的神经科学学科中优秀的医生培训生的职业发展，从而实现研究的独立性。培训将作为一个联合项目进行，利用当地神经科学界的多样化和广泛的资源，包括加州大学圣地亚哥分校、斯克里普斯研究基金会、索尔克研究所和伯纳姆基金会。项目的优秀申请者将从加州大学圣地亚哥分校神经科学系临床神经学项目的本地毕业生和即将毕业的住院医师中招募，以及从全国神经学培训项目中招募。每年申请2个名额，为期5年，共计培训职位。该项目将由神经科学部门管理，这是一个联合的基础科学临床部门。该学院在遗传、分子、细胞系统、神经系统和衰老研究的行为和建模方面具有相当大的实力。该培训计划将为被任命者提供三种类型的学术经验，以实现研究独立性。1)基础神经科学训练，通过正式的神经科学研究生课程工作和实验室研究轮转来完成；2)3-4年的密集指导研究；3)连续的专题讨论会、老龄化课程和讲座。拥有博士学位的受训者将有机会参加加州大学圣地亚哥分校神经科学研究生课程，并提前获得神经科学博士学位。该培训计划旨在让学员接触到神经科学主题的呼吸，这些主题需要从全面和学术的角度来处理与衰老相关的问题，范围从基因表达的研究到整个系统/行为方法。然后，每个受训者将选择一个学科，在其中集中和培养一个职业研究课题。

The purpose of this Mentored Clinical Scientist Development Program is to support the career development of outstanding physician trainees in an aging-related neuroscience discipline, leading to research independence. Training will be conducted as a joint program taking advantage of the diverse and extensive resource of the local neuroscience community, including the University of California-San Diego, Scripps Research Foundation, the Salk Institute, and the Burnham Foundation. Outstanding applicants for the program will be recruited both locally and graduating residents of the clinical neurology program in the Department of Neurosciences at UCSD, and from neurology training programs nationally. 2 slots per year are requested for a 5 year period, totaling training positions. The program will be administered by the Department of Neurosciences, a joint basic science clinical department. The faculty possesses considerable strength in the genetic, molecular, cellular systems, behavioral and modeling aspects of nervous system and aging research. The training program will provide appointees three types of academic experiences to lead to research independence. 1) Basic neuroscience training, accomplished by formal Neuroscience Graduate Program course work and laboratory research rotations, 2) a 3-4 year period of intensive mentored research, and 3) a continuous curriculum of symposia, coursework in aging, and lectures. Trainees who do have a Ph.D. degree will have the opportunity to enroll in the UCSD Neuroscience Graduate Program and early a Neuroscience doctoral degree. The training program intends to expose the trainees to a breath of neuroscience topics that are required to approach aging-related questions from a comprehensive and scholarly vantage point, ranging from the study of gene expression to whole systems/behavioral approaches. Individual trainees will then choose a discipline within which to focus and foster a career research topic.