CORE--CLINICAL

临床核心的主要目标将是招募和维持一个由ADRC的大约400名志愿者患者和对照组以及100名志愿者患者和对照组组成的小组，这是我们在丘拉维斯塔的卫星诊所发起的拉美裔倡议的一部分。中心将招募被诊断为轻度认知障碍(MCI)和极早期阿尔茨海默病(MMSE)(MMSE大于或等于20)的新受试者，以取代更严重受损的受试者。DRS得分大于或等于109的40名受试者将保持不变，以满足我们研究方案的需要。在这一竞争性更新周期中，我们将特别为Bondi博士的功能磁共振项目将我们的MCI池增加到100个。特别强调的是将继续 80岁以上的正常对照组的招募，以满足临床病理对照和生化研究对更多尸检脑的需求。年度参与者评估将包括人口统计、病史、医学神经学、精神病学和神经心理学检查，以帮助诊断并跟踪认知和神经进展的年度变化。这些评估提供了一个行为数据库，可供与ADRC相关的各种研究项目使用，此外还提供了有关AD过程和进展的纵向数据。临床核心维护着DNA、血浆、血清和脑脊液的库，供加州大学圣地亚哥分校的各种研究人员和其他机构和行业的合作者使用。临床核心中心提供了参与各种多中心临床试验和合作研究的资源，使用的对象和数据都是如此。最后，将开展开发工作，以提高我们诊断早期阿尔茨海默病的能力，并改善对其他痴呆的诊断，如路易体痴呆和额颞痴呆。

The principal objective of the Clinical Core will be to recruit and maintain a panel of approximately 400 volunteer patients and controls at the ADRC, and 100 volunteer patients and controls as part of our Hispanic initiative at our satellite clinic in Chula Vista. The Core will recruit new subjects with a diagnosis of Mild Cognitive Impairment (MCI) and very early AD (MMSE greater than or equal to 20) to replace subjects who have become more impaired. A pool of 40 subjects will be maintained with DRS scores greater than or equal to 109 to meet the needs of our research protocols. During this competitive renewal cycle we will specifically increase our pool of MCI subject to 100 for Dr. Bondi's project on functional MRI. Particular emphasis will continue to be placed on the recruitment of normal controls over the age of 80, in order to meet the need for greater numbers of autopsied brains for clinical-pathotogical correlations and biochemical studies. Annual participant evaluations will include demographic, history, medical neurological, psychiatric, and neuropsychological examinations to aid in the diagnosis and to track yearly changes in cognitive and neurological progression. The evaluations provide a behavioral database that can be used by the various research projects associated with the ADRC and in addition provide longitudinal data on the course and progression of AD. The Clinical Core maintains banks of DNA, plasma, serum, and CSF, used by various UCSD investigators and collaborators at other institutions and in industry. The Clinical Core provides the resources for participation in a variety of multi-center clinical trials and collaborative studies using both subjects and data. Finally developmental work will be undertaken to improve our ability to diagnose early AD and to improve the diagnosis of other dementias such as dementia with Lewy bodies and fronto-temporal dementia.