CORE--CLINICAL

核心--临床

• 批准号: 6797553
• 负责人: LEON J THAL
• 金额: $ 101.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797553
• 关键词: Alzheimer' s disease; Hispanic Americans; Lewy body; biomedical facility; brain disorder diagnosis; clinical research; clinical trials; cognition disorders; dementia; early diagnosis; genetic registry /resource /referral center; human genetic material tag; human old age (65+); human subject; longitudinal human study; neuropathology; neuropsychological tests; patient /disease registry; polymerase chain reaction; postmortem; tissue resource /registry

The principal objective of the Clinical Core will be to recruit and maintain a panel of approximately 400 volunteer patients and controls at the ADRC, and 100 volunteer patients and controls as part of our Hispanic initiative at our satellite clinic in Chula Vista. The Core will recruit new subjects with a diagnosis of Mild Cognitive Impairment (MCI) and very early AD (MMSE greater than or equal to 20) to replace subjects who have become more impaired. A pool of 40 subjects will be maintained with DRS scores greater than or equal to 109 to meet the needs of our research protocols. During this competitive renewal cycle we will specifically increase our pool of MCI subject to 100 for Dr. Bondi's project on functional MRI. Particular emphasis will continue to be placed on the recruitment of normal controls over the age of 80, in order to meet the need for greater numbers of autopsied brains for clinical-pathotogical correlations and biochemical studies. Annual participant evaluations will include demographic, history, medical neurological, psychiatric, and neuropsychological examinations to aid in the diagnosis and to track yearly changes in cognitive and neurological progression. The evaluations provide a behavioral database that can be used by the various research projects associated with the ADRC and in addition provide longitudinal data on the course and progression of AD. The Clinical Core maintains banks of DNA, plasma, serum, and CSF, used by various UCSD investigators and collaborators at other institutions and in industry. The Clinical Core provides the resources for participation in a variety of multi-center clinical trials and collaborative studies using both subjects and data. Finally developmental work will be undertaken to improve our ability to diagnose early AD and to improve the diagnosis of other dementias such as dementia with Lewy bodies and fronto-temporal dementia.

临床核心的主要目标是在ADRC招募和维护大约400名志愿患者和对照组的小组，并在Chula Vista的卫星诊所作为我们西班牙裔倡议的一部分，100名志愿者和对照组。核心将通过诊断为轻度认知障碍（MCI）和非常早的AD（MMSE大于或等于20）来招募新受试者，以替代变得更加受损的受试者。将维持40名受试者的池，以大于或等于109的DRS分数，以满足我们的研究方案的需求。在这个竞争激烈的续签周期中，我们将针对Bondi博士在功能性MRI的项目中专门增加MCI的池。特别重点将继续 放置在80岁以上正常对照的招募上，以满足对临床病理相关性和生化研究的大脑数量的需求。年度参与者评估将包括人口统计学，病史，医学神经系统，精神病学和神经心理学检查，以帮助诊断并跟踪认知和神经系统进展的年度变化。评估提供了一个行为数据库，可以由与ADRC相关的各种研究项目使用，此外还提供了有关AD课程和进展的纵向数据。临床核心维护了其他机构和行业中的各种UCSD研究人员和合作者使用的DNA，等离子体，血清和CSF的银行。临床核心提供了参与各种使用受试者和数据的各种多中心临床试验和协作研究的资源。最终，将进行发展工作，以提高我们诊断早期AD的能力，并改善其他痴呆症的诊断，例如Lewy Bodies和Fronto-Spero-Spero的痴呆症。