AIDS-ONCOLOGY CLINICAL SCIENTIST DEVELOPMENT PROGRAM

描述：(申请者的描述)由于存活率在 感染艾滋病毒的患者，很明显，更多的人 人们的寿命足够长，最终会患上恶性疾病。 此外，随着艾滋病流行的成熟，似乎谱系 与艾滋病毒相关的疾病的范围扩大了，恶性疾病成为 更突出的是，它是感染者的死因。除了 目前定义艾滋病的恶性肿瘤，包括卡波西肉瘤， 淋巴瘤和宫颈癌，其他类型的癌症现在正在 报告的艾滋病毒感染者中，有显著增加 肛门癌、何杰金氏病、肺癌的标化发病率 癌症、多发性骨髓瘤和其他疾病。在公共卫生政策方面，它 从这些数据中可以明显看出，我们国家的适当医疗保健 将需要在艾滋病毒疾病领域对肿瘤学家进行专门培训。在… 目前，还没有正式机制来提供这种 交叉培训，也没有为这种培训买单的机制。这个 这项培训补助金的目标将是培训这样的个人，他们将 然后准备好治疗感染艾滋病毒的恶性疾病患者； 在这一领域进行研究；并及时向其他人传授同样的知识 技能。该建议的具体目的是：(1)提供 全面、多学科的艾滋病毒临床培训，以 最近完成了一年或多年正式课程的个人 血液学/肿瘤学奖学金培训；(2)提供教学核心 课程，这将使人们对艾滋病毒的进展有一个广泛的了解 疾病本身，以及机会性癌症、感染和其他 随之而来的疾病；(3)提供教学核心课程，以及 在临床研究方法领域进行实用的日常培训，以 允许未来的临床研究人员在艾滋病相关领域发展 (4)提供基础科学领域的教学培训 研究方法，使未来的临床研究人员能够发展 将理解翻译研究在以下领域的原则 爱滋病--恶性肿瘤；以及(5)提供双方密切的指导支持 临床和基础科学导师，以确保 考生将从事与特定翻译研究相关的项目 涉及到艾滋病毒--恶性肿瘤领域。我们将提供为期两年的奖学金 程序。第一年将用于临床工作，分配的任务是 为每个实习生配备一名专门的临床导师。这一年将包括 每周去一次艾滋病毒/艾滋病普通诊所；每周一次艾滋病/淋巴瘤诊所； 每周一次的艾滋病/KS诊所；一个月的艾滋病毒/艾滋病住院病房；三个月 关于住院的爱滋病病区；出席说教讲座和 座谈会。第二年将侧重于临床和医疗方面的培训 艾滋病相关恶性肿瘤领域的翻译研究，与 指定具体的科学导师和研究的发展 项目，以及参加教育讲座和研讨会在 研究方法和生物学原理的领域。

DESCRIPTION: (Applicant's Description) As survival has increased in patients with HIV infection, it is apparent that greater numbers of individuals are living long enough to eventually develop malignant disease. Further, with maturation of the AIDS epidemic, it appears that the spectrum of HIV associated diseases has expanded, with malignant diseases becoming more prominent as the cause of death in infected individuals. Aside from the current AIDS-defining malignancies, including Kaposi's sarcoma, lymphoma, and cervical cancer, additional types of cancers are now being reported in HIV infected individuals, with significantly increased standardized incidence ratios (SIRs) of anal cancer, Hodgkin's disease, lung cancer, multiple myeloma and others. In terms of public health policy, it is apparent from these data that the appropriate health care of our nation will require specific training of oncologist in the area of HIV disease. At the present time, there is no formalized mechanism to provide such cross-training, nor is there a mechanism to pay for such training. The goals of this Training Grant will be to train such individuals, who will then be prepared to treat HIV infected patients with malignant disease; to conduct research in this area; and, in time, to teach others these same skills. The specific aims of the proposal are: (1) To provide comprehensive, multidisciplinary clinical training in HIV disease to individuals who have recently completed one or more years of formal fellowship training in Hematology'/Oncology; (2) To provide a didactic core curriculum, which will give a broad understanding of the advances in HIV disease, per se, as well as the opportunistic cancers, infections, and other illnesses which ensue; (3) To provide a didactic core curriculum, as well as practical, day-to-day training in the area of clinical research methods, to allow development of future clinical researchers in the area of AIDS-related malignancy; (4) To provide didactic training in the area of basic scientific research methods, to allow development of future clinical researchers who will understand the principles of translational research in the area of AIDS-malignancy; and (5) To provide close mentoring support from both clinical and basic scientific mentors, in order to assure that the candidates will engage in a specific translational research project related to the field of HIV-malignancies. We will offer a two-year Fellowship program. The first year will be spent in clinical work, with assignment of a specific clinical mentor to each Trainee. The year will consist of attendance at weekly general HIV/AIDS clinic; weekly AIDS/Lymphoma clinic; weekly AIDS/KS clinic; one month on in-patient HIV/AIDS ward; three months on inpatient AIDS malignancy ward; and attendance at didactic lectures and symposia. The second year will emphasize training in clinical and translational research in the area of AIDS-related malignancy, with assignment of specific scientific mentors, and development of research projects, as well as attendance at didactic lectures and symposia in the area of research methods and biologic principles.