AIDS-ONCOLOGY CLINICAL SCIENTIST DEVELOPMENT PROGRAM

描述：（申请人的描述）随着生存率的增加， 艾滋病毒感染者，很明显， 个体活得足够长，最终发展成恶性疾病。 此外，随着艾滋病流行病的成熟， 艾滋病毒相关疾病的发病率有所上升， 在受感染的个体中，它作为死亡的原因更为突出。 除了 目前艾滋病定义的恶性肿瘤，包括卡波西肉瘤， 淋巴瘤和宫颈癌，其他类型的癌症现在正在 报告的艾滋病毒感染者中， 肛门癌、何杰金氏病、肺癌的标准化发病率（SIRs） 癌症、多发性骨髓瘤和其他疾病。 在公共卫生政策方面， 从这些数据中可以明显看出，我们国家的适当医疗保健 将需要在艾滋病毒疾病领域对肿瘤学家进行专门培训。 在 目前，还没有正式机制来提供这种服务， 交叉培训，也没有支付这种培训的机制。 的 该培训补助金的目标将是培训这些人，他们将 然后准备治疗艾滋病病毒感染者的恶性疾病; 在这方面进行研究;并及时向其他人传授这些知识 skills. 建议的具体目标是：（1）提供 艾滋病毒疾病的全面、多学科临床培训， 最近完成一年或多年正式课程的个人 血液学/肿瘤学的奖学金培训;（2）提供教学核心 课程，这将使人们广泛了解艾滋病毒的进展 疾病本身，以及机会性癌症，感染，和其他 （3）提供教学核心课程，以及 在临床研究方法领域的实用，日常培训， 使未来的临床研究人员在艾滋病相关领域的发展 （4）在基础科学领域提供教学培训 研究方法，以允许未来的临床研究人员的发展， 将了解在该领域的翻译研究的原则， （5）提供密切的辅导支持， 临床和基础科学导师，以确保 候选人将从事特定的翻译研究项目相关 艾滋病病毒恶性肿瘤领域。 我们将提供为期两年的奖学金 程序. 第一年将在临床工作中度过， 为每位受训者指定一名临床导师。 今年将包括 参加每周一次的艾滋病毒/艾滋病普通门诊;每周一次的艾滋病/淋巴瘤门诊; 每周艾滋病/KS诊所;在住院艾滋病毒/艾滋病病房一个月;三个月 艾滋病恶性肿瘤住院病房;以及参加教学讲座， 专题讨论会。 第二年将强调临床和 艾滋病相关恶性肿瘤领域的转化研究， 指定具体的科学导师和开展研究 项目，以及出席在联合国的教学讲座和专题讨论会， 研究方法和生物学原理。

DESCRIPTION: (Applicant's Description) As survival has increased in patients with HIV infection, it is apparent that greater numbers of individuals are living long enough to eventually develop malignant disease. Further, with maturation of the AIDS epidemic, it appears that the spectrum of HIV associated diseases has expanded, with malignant diseases becoming more prominent as the cause of death in infected individuals. Aside from the current AIDS-defining malignancies, including Kaposi's sarcoma, lymphoma, and cervical cancer, additional types of cancers are now being reported in HIV infected individuals, with significantly increased standardized incidence ratios (SIRs) of anal cancer, Hodgkin's disease, lung cancer, multiple myeloma and others. In terms of public health policy, it is apparent from these data that the appropriate health care of our nation will require specific training of oncologist in the area of HIV disease. At the present time, there is no formalized mechanism to provide such cross-training, nor is there a mechanism to pay for such training. The goals of this Training Grant will be to train such individuals, who will then be prepared to treat HIV infected patients with malignant disease; to conduct research in this area; and, in time, to teach others these same skills. The specific aims of the proposal are: (1) To provide comprehensive, multidisciplinary clinical training in HIV disease to individuals who have recently completed one or more years of formal fellowship training in Hematology'/Oncology; (2) To provide a didactic core curriculum, which will give a broad understanding of the advances in HIV disease, per se, as well as the opportunistic cancers, infections, and other illnesses which ensue; (3) To provide a didactic core curriculum, as well as practical, day-to-day training in the area of clinical research methods, to allow development of future clinical researchers in the area of AIDS-related malignancy; (4) To provide didactic training in the area of basic scientific research methods, to allow development of future clinical researchers who will understand the principles of translational research in the area of AIDS-malignancy; and (5) To provide close mentoring support from both clinical and basic scientific mentors, in order to assure that the candidates will engage in a specific translational research project related to the field of HIV-malignancies. We will offer a two-year Fellowship program. The first year will be spent in clinical work, with assignment of a specific clinical mentor to each Trainee. The year will consist of attendance at weekly general HIV/AIDS clinic; weekly AIDS/Lymphoma clinic; weekly AIDS/KS clinic; one month on in-patient HIV/AIDS ward; three months on inpatient AIDS malignancy ward; and attendance at didactic lectures and symposia. The second year will emphasize training in clinical and translational research in the area of AIDS-related malignancy, with assignment of specific scientific mentors, and development of research projects, as well as attendance at didactic lectures and symposia in the area of research methods and biologic principles.