BIOMEDICAL OPTICS FOR MEDICAL RESEARCH AND CLINICAL CARE

用于医学研究和临床护理的生物医学光学

• 批准号: 6053731
• 负责人: STEVEN L. JACQUES
• 金额: $ 42.35万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-06 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053731
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomaterial development /preparation; biomedical equipment development; biomedical facility; clinical research; diagnosis design /evaluation; human subject; implant; laboratory mouse; laboratory rat; medical implant science; neoplasm /cancer diagnosis; optics; tissue engineering

Biomedical Optics is a field using light to interrogate tissues for diagnostic purposes and to treat disease and assist surgery, with applications in both biomedical research and clinical care. Oregon has a network of bioengineering laboratories specializing in biomedical optics and two medical centers with clinical activities using biomedical optics and medical lasers. This proposal would establish a Biomedical Optics Laboratory on the campus of the Oregon Health Sciences University (OHSU) as a core research facility to support the interface of new optical technologies from the bioengineering network with projects in the medical research and clinical activities at OHSU. The bioengineering network includes the Oregon Medical Laser Center at Providence St. Vincent Medical Center (OMLC), the Oregon Graduate Institute of Science and Technology (OGI), the Department of Biomaterials and Biomechanics (OHSU) and the University of Oregon Center for Optics (UO). The proposal would provide funding for the bioengineering network to initiate new projects for translation into the medical center. The design- directed projects of the bioengineering network are organized around hypothesis-driven projects of biomedical investigators and clinicians at the medical centers. The initial projects fall under two broad themes: (1) tissue engineering and biomaterials development with initial emphasis on bone regeneration and biomaterial implants, and (2) cancer detection and treatment with initial emphasis on optical imaging of dysplasia and superficial cancer, optical fiber devices for dosimetry and treatment evaluation during light-activated chemotherapy (photodynamic therapy or PDT), and PDT as a tool in basic medical research. Management and outreach activities of the program include an annual review by an external advisory board, a symposium at the annual Oregon Academy of Sciences meeting, and a website with extensive database and educational materials. The research program complements a Biomedical Optics curriculum.

生物医学光学是一个使用光来询问组织以进行诊断、治疗疾病和辅助手术的领域，在生物医学研究和临床护理中都有应用。俄勒冈州有一个专门从事生物医学光学的生物工程实验室网络，以及两个利用生物医学光学和医用激光开展临床活动的医疗中心。这项提议将在俄勒冈健康科学大学(OHSU)的校园内建立一个生物医学光学实验室，作为核心研究设施，以支持来自生物工程网络的新光学技术与OHSU医学研究和临床活动中的项目的接口。生物工程网络包括位于普罗维登斯圣文森特医学中心(OMLC)的俄勒冈医学激光中心(OMLC)、俄勒冈科技研究生院(OGI)、生物材料和生物机械系(OHSU)和俄勒冈大学光学中心(UO)。该提案将为生物工程网络提供资金，以启动新的项目，将其转化为医疗中心。生物工程网络的设计导向项目是围绕医学中心的生物医学研究人员和临床医生的假设驱动项目组织的。最初的项目有两大主题：(1)组织工程和生物材料开发，最初的重点是骨再生和生物材料植入；(2)癌症检测和治疗，最初的重点是异型增生和浅表性癌症的光学成像，光激活化疗(光动力疗法或PDT)期间用于剂量测量和疗效评估的光纤设备，以及PDT作为基础医学研究的工具。该计划的管理和推广活动包括外部顾问委员会的年度审查，俄勒冈州科学院年度会议上的研讨会，以及一个拥有大量数据库和教育材料的网站。该研究项目是对生物医学光学课程的补充。