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CRYSTAL STRUCTURE OF CYTOSKELETAL PROTEIN, VINCULIN

CRYSTAL STRUCTURE OF CYTOSKELETAL PROTEIN, VINCULIN
细胞骨架蛋白，纽蛋白的晶体结构
批准号：
6339373
负责人：
ROBERT Colin LIDDINGTON
金额：
$0.69万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-08-15 至 2001-08-14
来源：
https://reporter.nih.gov/project-details/6339373
关键词：
biomedical resource structural biology

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Vinculin is large protein of MW 120 KDa, of unknown structure, which plays a central role in the assembly of focal adhesions. These are macromoleular complexes found at cell-matrix junctions, which provide a structural and functional link between the extracellular matrix and the actin cytoskeleton. Much is known about the binding activities of vinculin in vitro, and the field is well poised to benefit from structural data at atomic resolution, which would elucidate the structural basis of focal adhesion assembly and regulation
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