CRYSTALLOGRAPHIC STUDIES OF CYTOKINE RECEPTOR ECTODOMAIN & EXOGLUCANASE

细胞因子受体胞外域的晶体学研究

• 批准号: 6339374
• 负责人: JOSE VARGHESE
• 金额: $ 0.69万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2001-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6339374
• 关键词: biomedical resource; structural biology

This cytokine receptor binds an important cytokine involved in diverse cellular regulatory activity. The structure will help understanding the cytokinefs related cellular activity and perhaps able to modulate this activity. Crystals have been grown in a tetragonal space group with cell edges 50 x 50 x 300 A. Crystals are very radiation sensitive, and current freezing techniques have caused some kind of disorder in the lattice. Two hour exposures on a rotating anode give diffraction data up to 3.5A. It is expected that better than 3A data can be obtained at the APS.

这种细胞因子受体结合一种重要的细胞因子， 多样的细胞调节活性。 结构将有助于 了解与细胞活动相关的细胞因子， 能够调节这种活动。 晶体生长在 四面体空间群，晶胞边缘为50 × 50 × 300。晶体 对辐射非常敏感，目前的冷冻技术已经导致 晶格中的某种无序 两小时曝光， 旋转阳极给出衍射数据高达3.5A。 预计在 在APS处可以获得优于3A的数据。