SUSCEPTIBILITY CONTRAST IN NMR IMAGING

本项目的总体目标是理解和利用 磁化率微观变化的宏观效应 核磁共振(核磁共振)成像。微观 局部磁场的变化可能会产生巨大的变化 核磁共振图像对比度。我们试图从数量上理解一个 这种敏感性对比的广泛来源： 可靶向、纳米尺寸的超顺磁性粒子的分布； 脱氧血红蛋白对心脏的血管内外效应 血管系统；以及使用这些现象来量化非 体内侵袭性血管大小分布。我们结合了 随机游走的蒙特卡罗模拟和实验研究 动物模型，以便定义和探索我们的 了解敏感度对比，以及我们的能力 利用这一理解进行生理测量。

The overall goal of this project is to understand and exploit the macroscopic effects of microscopic susceptibility variation in Nuclear Magnetic Resonance (NMR) imaging. Microscopic variations in local magnetic fields can produce large changes in NMR image contrast. We seek to understand quantitatively a broad range of sources of this susceptibility contrast: effects of the distribution of targettable, nano-sized superparamagnetic particles; intra- and extravascular effects of deoxyhemoglobin in cardiac vasculature; and the use of these phenomena for quantifying non- invasively the distribution of vessels size in vivo. We combine Monte Carlo random walk simulations and experimental studies in animal models in order to define and probe both our understanding of susceptibility contrast, as well as our ability to exploit this understanding for physiological measurement.