SUSCEPTIBILITY CONTRAST IN NMR IMAGING

核磁共振成像中的磁化率对比

• 批准号: 6237021
• 负责人: ROBERT M WEISSKOFF
• 金额: $ 12.99万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-17 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6237021
• 关键词: angiography; biological models; biomagnetism measurement; computer simulation; contrast media; diffusion; dogs; functional magnetic resonance imaging; hemoglobin; image processing; laboratory rat; magnetic field; noninvasive diagnosis; nuclear magnetic resonance spectroscopy

The overall goal of this project is to understand and exploit the macroscopic effects of microscopic susceptibility variation in Nuclear Magnetic Resonance (NMR) imaging. Microscopic variations in local magnetic fields can produce large changes in NMR image contrast. We seek to understand quantitatively a broad range of sources of this susceptibility contrast: effects of the distribution of targettable, nano-sized superparamagnetic particles; intra- and extravascular effects of deoxyhemoglobin in cardiac vasculature; and the use of these phenomena for quantifying non- invasively the distribution of vessels size in vivo. We combine Monte Carlo random walk simulations and experimental studies in animal models in order to define and probe both our understanding of susceptibility contrast, as well as our ability to exploit this understanding for physiological measurement.

该项目的总体目标是了解和利用 微观磁化率变化的宏观影响 核磁共振 (NMR) 成像。 微观的 局部磁场的变化会产生巨大的变化 核磁共振图像对比度。我们试图定量地理解 这种敏感性对比的广泛来源： 可瞄准的纳米级超顺磁颗粒的分布； 脱氧血红蛋白对心脏血管内和血管外的影响 脉管系统；以及利用这些现象来量化非 体内血管尺寸的侵入性分布。 我们结合 蒙特卡罗随机游走模拟和实验研究 动物模型，以定义和探索我们的 对敏感性对比的理解，以及我们的能力 利用这种理解进行生理测量。