FUNCTIONAL MRI TECHNICAL DEVELOPMENT

功能性 MRI 技术开发

• 批准号: 6238023
• 负责人: ROBERT M WEISSKOFF
• 金额: $ 17.71万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238023
• 关键词: brain mapping; cocaine; drug addiction; functional magnetic resonance imaging; human data; image enhancement; method development

This project will develop new methods for imaging cocaine-induced activation in humans and in rats using functional magnetic resonance imaging (fMRI) techniques. These techniques have the potential for analyzing non-invasively both direct vascular and euphoric responses, as well as drug-dependent behavior such as craving, with unprecedented temporal and spatial resolution. However, while fMRI has been very successful in its preliminary applications of mapping primary sensory cortices, studies of sub-cortical structures have been less fruitful. Since these sub-cortical structures appear key to understanding the physiology of drug-dependent behavior, our proposed work seeks to extend fMRI imaging sequences, map generation, and analysis techniques to optimize the detection of cocaine-induced activation. These methods address the specific issues that make fMRI unique among functional neuroimaging modalities: the mixture of sequence-dependent functional weightings available, the high spatial and temporal resolution feasible, and the unique statistical characteristics of the functional MR data. By combining novel imaging and analysis techniques, we thus seek to establish functional MR imaging as a rigorous methodology for the study of drug response and drug-dependent behavior in humans.

该项目将开发可卡因诱导成像的新方法 使用功能磁共振在人类和大鼠中激活 成像（fMRI）技术。 这些技术有潜力 非侵入性地分析直接血管反应和欣快反应，如 以及药物依赖行为，例如渴望，具有前所未有的 时间和空间分辨率。 然而，虽然功能磁共振成像已经非常 在绘制初级感官图谱方面取得了初步应用成功 皮层，皮层下结构的研究成果较少。 由于这些皮层下结构似乎是理解 药物依赖性行为的生理学，我们提出的工作旨在扩展 fMRI 成像序列、图谱生成和分析技术 优化可卡因诱导激活的检测。 这些方法 解决使 fMRI 在功能性磁共振成像中独一无二的具体问题 神经影像模式：序列依赖性功能的混合 可用的权重，高空间和时间分辨率可行， 以及功能 MR 数据的独特统计特征。 通过结合新颖的成像和分析技术，我们寻求 建立功能性 MR 成像作为严格的研究方法 人类的药物反应和药物依赖性行为。