DIFFRACTION ENHANCED IMAGING APPLIED TO MAMMOGRAPHY

衍射增强成像应用于乳房X线照相术

• 批准号: 6182180
• 负责人: LEROY D CHAPMAN
• 金额: $ 7.18万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6182180
• 关键词: X ray crystallography; bioimaging /biomedical imaging; biomedical equipment development; diagnosis design /evaluation; female; human tissue; image enhancement; mammography; synchrotrons

DESCRIPTION (Adapted from Applicant's Abstract): Screening mammography has proven to be an effective procedure for the detection of early breast cancer. However, a significant fraction of cancer escapes detection due to dense glandular tissue which obscures the underlying pathology. Diffraction Enhanced x-ray Imaging (DEI) has the potential to dramatically change mammography and radiography in general. Specifically developed as part of an x-ray mammography program utilizing monochromatic x-rays from a synchrotron source, this technique has produced images of test objects and issue whose contrast and information content far exceeds conventional techniques. Preliminary work with human breast cancer specimens suggests that DEI images include information regarding specific physical characteristics of the lesion including border detail and associated features that are not detected by conventional imaging. The long term goal of this program is to develop a clinical based DEI system for mammography. The first phase of this program is to identify the optimal DEI parameters for improved visualization of lesions of the breast and to use these parameters to develop a conceptual design of a clinical DEI system. The synchrotron provides the ideal environment to perform these pilot studies since it provides a very intense, collimated, and tunable source of x-radiation. Specifically, a study of human breast tissue samples with cancer will be performed in which the DEI parameters will be systematically assessed regarding the visibility of structures suggestive of breast cancer-namely, spiculation architectural distortion, and calcification. This study will include the assessment of a wide variety of DEI parameters including imaging energy, refraction/scatter-rejection sensitivity, location on the "rocking curve," and x-ray optical geometry. The intent of this study is to optimize DEI for the clinical task. This will allow us to specify the x-ray source, x-ray optics, and detection method requirements for a clinical based system. As a result of this work the applicants propose to develop a conceptual design for a clinical system for mammography using DEI.

描述（改编自申请人的摘要）：筛查乳房X线摄影具有 被证明是检测早期乳腺癌的有效方法。 然而，由于密集的肿瘤，很大一部分癌症逃脱了检测。 掩盖了潜在病理的腺体组织。衍射增强 X射线成像（DEI）有可能极大地改变乳房X光检查， 一般的放射学。专门开发的X射线乳房造影术的一部分 计划利用单色X射线从同步辐射源，这 该技术已经产生了测试对象和问题的图像， 信息量远远超过传统技术。初步工作， 人类乳腺癌标本表明，DEI图像包括信息， 关于病变的具体物理特征，包括边界 细节和相关特征不能被常规成像检测到。 该项目的长期目标是开发一种基于临床的DEI系统 乳房X光检查该计划的第一阶段是确定最佳DEI 用于改善乳房病变的可视化的参数，并使用这些参数 参数来开发临床DEI系统的概念设计。的 同步加速器为进行这些试验性研究提供了理想的环境， 它提供了非常强烈的、准直的和可调谐的X辐射源。 具体来说，将对患有癌症的人类乳腺组织样本进行研究， 进行DEI参数的系统评估， 提示乳腺癌的结构的可见性-即毛刺 建筑变形和钙化。这项研究将包括 评估各种DEI参数，包括成像能量， 折射/散射抑制灵敏度，“摇摆曲线”上的位置，以及 X射线光学几何学。本研究的目的是优化DEI， 临床任务这将使我们能够指定X射线源，X射线光学， 以及基于临床的系统的检测方法要求。的结果 申请人提出的这项工作是开发一种用于临床治疗的概念设计。 使用DEI的乳房X线摄影系统。

项目成果

Diffraction enhanced imaging contrast mechanisms in breast cancer specimens.

• DOI: 10.1118/1.1507782
• 发表时间: 2002-10
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: M. Hasnah;Z. Zhong;O. Oltulu;E. Pisano;R. E. Johnston;D. Sayers;W. Thomlinson;D. Chapman