CORE--IMAGING TECHNIQUES FOR ADPKD

核心——ADPKD 成像技术

• 批准号: 6105262
• 负责人: MICHAEL L MANCO-JOHNSON
• 金额: $ 17.98万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6105262
• 关键词: autosomal dominant trait; barium; bioimaging /biomedical imaging; biomedical facility; clinical research; computed axial tomography; diagnosis design /evaluation; human subject; kidney disorder diagnosis; kidney imaging /visualization; polycystic kidney; radionuclide diagnosis; radionuclides; radiotracer; ultrasonography

The specific aim of this core is to provide essential imaging support for projects in the grant. In addition to continuing the use of ultrasound to diagnose autosomal dominant polycystic kidney disease (ADPKD), ultrasound will be used to assess the natural history of ADPKD by longitudinally imaging patients. Liver and kidney volume, percentage of normal parenchyma, and percentage of cyst involvement will be measured. Selected pregnant patients will be imaged to determine earliest manifestation of ADPKD in utero and the fetuses will be evaluated for renal size, echogenicity, and presence or absence of renal cysts. Growth of the fetal liver and fetal kidneys will also be monitored. Extrarenal manifestations of the disease will be evaluated. Intracranial aneurysms will be evaluated primarily by dynamic computed tomography with angiography for confirmation of suspicious lesions. Certain ADPKD patients will be evaluated for diverticula by air-contrast barium enema.

该核心的具体目的是为 赠款中的项目。 除了继续使用超声 诊断常染色体显性多囊性肾脏疾病（ADPKD），超声 将通过纵向评估ADPKD的自然历史 成像患者。 肝脏和肾脏体积，正常的百分比 将测量实质和囊肿受累的百分比。 选定 孕妇将成像以确定最早的表现 子宫内的ADPKD和胎儿的肾脏大小将评估 回声性，肾囊肿的存在或不存在。 胎儿的生长 肝脏和胎儿肾脏也将受到监测。 外表现 将评估该疾病的疾病。 将评估颅内动脉瘤 主要通过动态计算机断层扫描和血管造影进行确认 可疑病变。 某些ADPKD患者将进行评估 空气对比钡灌肠的憩室。