Stadardized Assesment of Swallowing Impairment

描述（由申请人提供）：候选人对该奖项机制的兴趣源于她的职业道路，其中包括将有意义的以患者为导向的研究整合到评估和治疗吞咽障碍患者的临床实践中。候选人的最终职业目标是独立研究和定义慢性肺病成人患者的功能性吞咽障碍;然而，目前还没有经过验证或可靠的测量工具可以检测和量化吞咽障碍。慢性肺病患者独立吞咽研究的未来途径的初步步骤将需要开发一种吞咽障碍测量工具，用于改良钡剂吞咽评估。该工具（MBSImp）将具有临床意义，实际实施，可靠评分，并对观察到的误吸的存在以及健康和生活质量的外部指标敏感。该奖项的结构提供了一种工具，以促进这些短期和长期目标的实现，并使候选人从临床卓越和早期临床科学家成功发展为独立的临床研究人员。在研究计划中提出了一个复杂的减少和聚合策略，需要应用多元统计分析，测量理论和规模的发展，因素分析和潜变量建模的知识。候选人包括一位导师和外部顾问，以监督她的职业规划中的综合课程，其中包括教学课程和统计设计，测量和因素分析领域的独立研究。实现候选人的既定职业目标将需要全面了解上呼吸消化道的大体解剖学，生理学和病理生理学。作为吞咽和吞咽障碍领域的临床科学家，高级能力需要理解和应用重叠的吞咽生理学。虽然Martin-Harris博士在口咽吞咽动力学和肺功能的临床研究方面表现出很强的临床熟练程度，但她对颈部、胸部和远端食管结构和功能的了解不足。肺部疾病患者和研究计划中研究的前瞻性患者通常同时存在口咽和食管吞咽障碍。因此，候选人包括先进的头部，颈部和胸部解剖学，头部和颈部手术旋转的教学课程，以及与她的主要导师，世界知名的临床医生和食管吞咽障碍研究人员的独立研究。

DESCRIPTION (provided by applicant): The origin of the candidate's interest in this award mechanism stems from her career pathway that has included the integration of meaningful patient-oriented research into the clinical practice of evaluating and treating patients with swallowing disorders. The ultimate career goal of the candidate is to independently study and define functional swallowing impairment in adult patients with chronic pulmonary disease; however, there exists no validated or reliable measurement tool that permits the detection and quantification of swallowing impairment. A preliminary step toward the future pathway of independent swallowing research of patients with chronic pulmonary disease will require the development of a swallowing impairment measurement tool to be used during the modified barium swallowing evaluation. This tool (the MBSImP) will be clinically meaningful, practically implemented, reliably scored and sensitive to the presence of observed aspiration and to external indicators of health and quality of life. The structure of this award provides a vehicle to facilitate achievement of these short-term and long-term goals, and to the candidate's successful progression from clinical excellence and early stage clinical scientist to an independent clinical researcher. A complex reduction and aggregation strategy is proposed in the research plan that requires knowledge of applied multivariate statistical analyses, measurement theory and scale development, factor analysis and latent variable modeling. The candidate has included a mentor and external advisor to oversee a comprehensive curriculum in her Career Plan that includes didactic coursework and independent studies in the areas of statistical design, measurement, and factor analysis. Achievement of the candidate's stated career goals will require comprehensive understanding of the gross anatomy, physiology and pathophysiology of the upper aerodigestive tract in its entirety. Advanced competency as a clinical scientist in the area of swallowing and swallowing disorders will require understanding and application of overlapping swallowing physiology. While Dr. Martin-Harris demonstrates strong clinical proficiency in the clinical study of oropharyngeal swallowing dynamics and pulmonary function, she has insufficient knowledge of cervical, thoracic and distal esophageal structure and function. Patients with pulmonary disease and the prospective patients to be studied in the research plan often present with coexisting oropharyngeal and esophageal swallowing disorders. Therefore, the Candidate has included didactic coursework in advanced head, neck and chest anatomy, head and neck surgical rotations, and independent studies with her primary mentor, a world renowned clinician and researcher of esophageal swallowing disorders.