Stadardized Assesment of Swallowing Impairment

吞咽障碍的标准化评估

• 批准号: 6884653
• 负责人: BONNIE J MARTIN-HARRIS
• 金额: $ 19.65万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884653
• 关键词: barium; bioimaging /biomedical imaging; body composition; clinical research; dietary restriction; dysphagia; gastrointestinal disorder diagnosis; gastrointestinal imaging /visualization; health surveys; human subject; patient oriented research; quality of life; training

DESCRIPTION (provided by applicant): The origin of the candidate's interest in this award mechanism stems from her career pathway that has included the integration of meaningful patient-oriented research into the clinical practice of evaluating and treating patients with swallowing disorders. The ultimate career goal of the candidate is to independently study and define functional swallowing impairment in adult patients with chronic pulmonary disease; however, there exists no validated or reliable measurement tool that permits the detection and quantification of swallowing impairment. A preliminary step toward the future pathway of independent swallowing research of patients with chronic pulmonary disease will require the development of a swallowing impairment measurement tool to be used during the modified barium swallowing evaluation. This tool (the MBSImP) will be clinically meaningful, practically implemented, reliably scored and sensitive to the presence of observed aspiration and to external indicators of health and quality of life. The structure of this award provides a vehicle to facilitate achievement of these short-term and long-term goals, and to the candidate's successful progression from clinical excellence and early stage clinical scientist to an independent clinical researcher. A complex reduction and aggregation strategy is proposed in the research plan that requires knowledge of applied multivariate statistical analyses, measurement theory and scale development, factor analysis and latent variable modeling. The candidate has included a mentor and external advisor to oversee a comprehensive curriculum in her Career Plan that includes didactic coursework and independent studies in the areas of statistical design, measurement, and factor analysis. Achievement of the candidate's stated career goals will require comprehensive understanding of the gross anatomy, physiology and pathophysiology of the upper aerodigestive tract in its entirety. Advanced competency as a clinical scientist in the area of swallowing and swallowing disorders will require understanding and application of overlapping swallowing physiology. While Dr. Martin-Harris demonstrates strong clinical proficiency in the clinical study of oropharyngeal swallowing dynamics and pulmonary function, she has insufficient knowledge of cervical, thoracic and distal esophageal structure and function. Patients with pulmonary disease and the prospective patients to be studied in the research plan often present with coexisting oropharyngeal and esophageal swallowing disorders. Therefore, the Candidate has included didactic coursework in advanced head, neck and chest anatomy, head and neck surgical rotations, and independent studies with her primary mentor, a world renowned clinician and researcher of esophageal swallowing disorders.

描述（由申请人提供）：候选人对这种奖励机制的兴趣的起源源于她的职业途径，其中包括将有意义的以患者为导向的研究整合到评估和治疗吞咽疾病患者的临床实践中。候选人的最终职业目标是独立研究和定义慢性肺部疾病患者的功能性吞咽障碍。但是，没有验证或可靠的测量工具可以允许检测和量化吞咽损伤。朝着未来吞咽研究的慢性肺部疾病研究的未来途径的初步步骤将需要开发在改良的钡吞咽评估期间使用吞咽损伤测量工具。该工具（MBSIMP）将在临床上有意义，实际实施，可靠地得分并敏感到观察到的愿望以及健康和生活质量的外部指标。该奖项的结构为促进这些短期和长期目标的实现提供了一种工具，以及候选人从临床卓越和早期临床科学家到独立临床研究人员的成功发展。研究计划中提出了复杂的减少和聚合策略，该策略需要了解应用多元统计分析，测量理论和规模发展，因子分析和潜在可变建模。候选人包括一位导师和外部顾问，以监督其职业计划中的全面课程，其中包括教学课程和统计设计，测量和因素分析领域的独立研究。实现候选人的职业目标将需要全面地了解上层机修区的总体解剖学，生理和病理生理学。作为吞咽和吞咽障碍领域的临床科学家的高级能力将需要理解和应用重叠的吞咽生理学。马丁·哈里斯（Martin-Harris）博士在口咽吞咽动力学和肺功能方面表现出强大的临床水平，但她对宫颈，胸腔和远端食管结构和功能的了解不足。在研究计划中研究肺部疾病和前瞻性患者的患者经常出现共存的口咽和食管吞咽疾病。因此，该候选人包括高级头部，颈部和胸部解剖结构，头颈外科手术旋转的教学课程，以及与她的主要导师的独立研究，她的主要临床医生和食管吞咽疾病的研究人员。