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Does the fruitless gene influence species-specific variation in mating behaviour?

无结果基因是否会影响交配行为的物种特异性变异？

基本信息

批准号：
NE/J023647/1
负责人：
Stephen Goodwin
金额：
$ 44.64万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2012
资助国家：
英国
起止时间：
2012 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=NE%2FJ023647%2F1
关键词：
Does fruitless gene influence species

项目摘要

Genes responsible for variation in species-specific mating signals may be important to speciation and biodiversity because evolutionary divergence in these loci can play a role in promoting sexual isolation and decreasing gene flow between natural populations of diverging species. Identifying and studying the divergence of such genes is a key priority of contemporary evolutionary genetics. In a series of QTL studies of divergence of song traits between and within species of the fruit fly Drosophila, the gene fruitless (fru) has been implicated in the control of variation in this classic trait. Much is known about the structure and function of this gene in controlling song production in D. melanogaster, but little if anything about its role in influencing natural variation in song. We propose a) developing a combination of advanced 'gene swap' techniques to move exons of the gene from a range of species into D. melanogaster b) studies of the molecular evolution of fru within and between natural populations and species c) association analysis of variation in fru and traits in natural populations and d) examination of the evolution of regulatory regions to assess in detail the role of fru in natural variation at multiple levels. This will represent a uniquely detailed examination of the evolution of a candidate locus for a complex behavioural trait.

负责物种特异性交配信号变异的基因可能对物种形成和生物多样性很重要，因为这些基因座的进化分歧可以在促进性隔离和减少不同物种的自然种群之间的基因流动方面发挥作用。识别和研究这些基因的分歧是当代进化遗传学的一个关键优先事项。在一系列的QTL研究分歧的歌曲性状之间和物种内的果蝇，基因fruitless（fru）已牵连在控制这一经典性状的变化。目前对该基因的结构和功能了解较多。黑腹果蝇，但很少，如果有的话，它的作用，影响自然变化的歌曲。我们提出a）发展一种先进的“基因交换”技术的组合，将基因的外显子从一系列物种转移到D。黑腹果蝇B）在自然种群和物种内和之间的fru分子进化研究c）fru变异与自然种群性状的关联分析和d）检查调节区的进化以详细评估fru在多个水平的自然变异中的作用。这将代表一个独特的详细审查的候选基因座的复杂的行为特征的演变。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.

DOI：
10.1016/j.cub.2013.11.035
发表时间：
2014-02-03
期刊：
CURRENT BIOLOGY
影响因子：
9.2
作者：
Neville, Megan C.;Nojima, Tetsuya;Ashley, Elizabeth;Parker, Darren J.;Walker, John;Southall, Tony;Van de Sande, Bram;Marques, Ana C.;Fischer, Bettina;Brand, Andrea H.;Russell, Steven;Ritchie, Michael G.;Aerts, Stein;Goodwin, Stephen F.
通讯作者：
Goodwin, Stephen F.

The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons.

保守基因的新颖性的进化；