Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior.
Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior.
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作者：
Nojima T;Neville MC;Goodwin SF
求偶是整个动物王国成功繁殖的关键。神经系统的性别差异被认为是求爱行为的基础。果蝇的雄性求偶行为在很大程度上是由fruitless（fru）基因调控的。据报道，fru编码至少三种推定的BTB-锌指转录因子，预测其具有不同的DNA结合特异性。尽管大量的研究已经证明fru在雄性求偶行为中起着重要的作用，但我们对Fru异构体在分子水平上的功能知之甚少。我们最近的研究表明，男性特定的Fru亚型表达在男性大脑和腹神经索的神经元的高度重叠的子集。在雄性求偶行为中，Fru基因的异构体扮演着不同的和多余的角色。重要的是，我们已经确定了第一次，通过DamID技术，直接Fru转录靶基因。Fru靶基因绝大多数代表先前报道的参与神经系统发育的基因，如CadN、lola和pdm 2。我们的研究为了解生殖行为背后的性二态神经回路是如何建立的提供了重要见解。
Courtship is pivotal to successful reproduction throughout the animal kingdom. Sexual differences in the nervous system are thought to underlie courtship behavior. Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). fru has been reported to encode at least three putative BTB-zinc-finger transcription factors predicted to have different DNA-binding specificities. Although a large number of previous studies have demonstrated that fru plays essential roles in male courtship behavior, we know little about the function of Fru isoforms at the molecular level. Our recent study revealed that male-specific Fru isoforms are expressed in highly overlapping subsets of neurons in the male brain and ventral nerve cord. Fru isoforms play both distinct and redundant roles in male courtship behavior. Importantly, we have identified for the first time, by means of the DamID technique, direct Fru transcriptional target genes. Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as CadN, lola and pdm2. Our study provides important insight into how the sexually dimorphic neural circuits underlying reproductive behavior are established.
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