LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS)

液相色谱-质谱联用仪 (LC-MS)

• 批准号: 2791796
• 负责人: Zora Djuric
• 金额: $ 18.26万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2791796
• 关键词: analytical chemistry; biomedical equipment; biomedical equipment purchase; liquid chromatography; mass spectrometry

Liquid chromatography (LC) combined with mass spectral (MS) detection is currently not available at Wayne State University. This analytical tool is very much needed by the applicants for a variety of ongoing projects involving characterization and identification and identification of: modified DNA and RNA components, drug metabolites and products of chemical syntheses. The application lists six major users who are all funded by the NIH. The LC-MS instrument would provide for analyses that are either more sensitive, less prone to artefact formation, much less time consuming or not possible with the current instrumentation. The LC- MS instrument that we request will be housed and maintained by the Central Instrument Facility of Wayne State University. This facility has funding from a number of internal and external sources, assuring proper care of the LC-MS over the long term. The Central Instrument Facility also provides Ph.D.-level expertise in chromatographic and mass spectral techniques and has well-developed procedures for shared instrument use. In summary, the need for LC-MS at our institution is clearly present for at least six NIH-funded users and we have the ability to operate and maintain this instrument throughout its useful life.

液相色谱（LC）结合质谱（MS）检测目前在韦恩州立大学不可用。申请人非常需要这种分析工具，用于各种正在进行的项目，包括表征和鉴定：修饰的DNA和RNA组分，药物代谢物和化学合成产物。该应用程序列出了六个主要用户，他们都由NIH资助。LC-MS仪器将提供更灵敏、更不易形成伪影、耗时少得多或用当前仪器不可能的分析。我们要求的LC- MS仪器将由韦恩州立大学的中央仪器设施安置和维护。该设施有来自内部和外部的资金来源，确保LC-MS的长期妥善照顾。中央仪器设施还提供博士学位-在色谱和质谱技术方面具有高水平的专门知识，并有完善的共享仪器使用程序。总之，我们机构对LC-MS的需求显然存在于至少六个NIH资助的用户中，我们有能力在整个使用寿命期间操作和维护该仪器。