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ACQUISITION OF A 400 MHZ NMR INSTRUMENT

购买 400 MHZ NMR 仪器

基本信息

批准号：
2803040
负责人：
STEPHEN L BUCHWALD
金额：
$ 29.6万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-05-01 至 2000-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2803040
关键词：
biomedical equipment biomedical equipment purchase nuclear magnetic resonance spectroscopy

项目摘要

Rapid sample throughput is essential for multi-user scientific instruments located in central core facilities such as the Department of Chemistry's Instrumentation Facility (DCIF) at the Massachusetts Institute of Technology (MIT). Funds are requested from the NIH to assist in the purchase of a complete 400 MHz nuclear magnetic resonance (NMR) instrument to better serve 104 researchers from the groups of this proposal's seven Major Users. The requested instrument will replace a 13-year-old Varian XL-300 instrument (which has recently experienced considerable down time including a magnet quench) and will sere as the primary workhorse instrument for researchers working on a wide array of NIH-funded research programs. The inclusion of a modern 400 MHz NMR instrument in the DCIF at MIT is an integral part of a major initiative- -including the recent $540,000 renovation of the DCIF--to upgrade and modernize the instrument services provided to Departmental and other academic researchers. The increased efficiency, enhanced biologically- related research in the Department. Projects that will benefit from the acquisition of this instrument include the following: asymmetric catalysis, new reaction development, total synthesis, electron transfer studies, oligosaccharide synthesis, and investigations of peptide conformation. At present, all but one of the DCIF's NMR instruments is severely outdated. Even the DCIF's newest NMR instrument (a Unity 300 with a widebore magnet intended for solid-state work) is eight year old. All other NMR instruments are more than ten years old excepting a Bruker AC-250 which is nine years old. The lack of modern and efficient NMR instrumentation in the DCIF negatively impacts productivity. NIH-funded research on small and intermediate size molecules being carried out in the Department would be greatly facilitated by a 400 MHz NMR instrument with increased sensitivity, internet access for moving data, an automatic sample change, rapid autoshimming capability, and a four- nucleus probe.

快速样品通量对于位于中央核心设施（例如马萨诸塞州理工学院（MIT）化学系仪器设施（DCIF））的多用户科学仪器至关重要。美国国立卫生研究院要求提供资金，协助购买一台完整的400 MHz核磁共振（NMR）仪器，以更好地为该提案的七个主要用户群体中的104名研究人员提供服务。所要求的仪器将取代已有13年历史的Varian XL-300仪器（该仪器最近经历了相当长的停机时间，包括磁体淬火），并将成为研究人员在NIH资助的各种研究项目中工作的主要主力仪器。在麻省理工学院的DCIF中纳入现代400 MHz NMR仪器是一项重大举措的组成部分-包括最近对DCIF进行的540，000美元翻新-以升级和现代化为部门和其他学术研究人员提供的仪器服务。效率的提高促进了系里与生物学相关的研究.将从该仪器的收购中受益的项目包括：不对称催化、新反应开发、全合成、电子转移研究、寡糖合成和肽构象研究。目前，DCIF的NMR仪器中只有一台严重过时。即使是DCIF最新的NMR仪器（带有用于固态工作的宽孔磁铁的Unity 300）也有八年的历史。所有其他核磁共振仪器都超过十年，除了布鲁克AC-250是九岁。DCIF中缺乏现代化和高效的NMR仪器对生产率产生了负面影响。由NIH资助的在该部门进行的小分子和中等大小分子的研究将大大促进具有更高灵敏度的400 MHz NMR仪器，移动数据的互联网接入，自动样品更换，快速自动匀场能力和四核探针。

项目成果

期刊论文数量（90）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties.

DOI：
10.1021/nn401905g
发表时间：
2013-07-23
期刊：
ACS NANO
影响因子：
17.1
作者：
Johnstone, Timothy C.;Kulak, Nora;Pridgen, Eric M.;Farokhzad, Omid C.;Langer, Robert;Lippard, Stephen J.
通讯作者：
Lippard, Stephen J.

Macrocyclization by nickel-catalyzed, ester-promoted, epoxide-alkyne reductive coupling: total synthesis of (-)-gloeosporone.

DOI：
10.1002/anie.200902079
发表时间：
2009
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
影响因子：
16.6
作者：
Trenkle, James D.;Jamison, Timothy F.
通讯作者：
Jamison, Timothy F.

Highly branched and loop-rich gels via formation of metal-organic cages linked by polymers.

DOI：
10.1038/nchem.2390
发表时间：
2016-01
期刊：
Nature chemistry
影响因子：
21.8
作者：
Zhukhovitskiy AV;Zhong M;Keeler EG;Michaelis VK;Sun JE;Hore MJ;Pochan DJ;Griffin RG;Willard AP;Johnson JA
通讯作者：
Johnson JA

Zinc thiolate reactivity toward nitrogen oxides: insights into the interaction of Zn2+ with S-nitrosothiols and implications for nitric oxide synthase.