BECKMAN SYNCHRON CX5 DELTA CHEMISTRY ANALYSIS SYSTEM

新的基因技术结合良好的基因组特征使小鼠成为人类疾病的首选哺乳动物模型。研究人员必须能够从遗传学和生理学上描述它们的特征，以充分利用它们的生物医学潜力。为了实现这一潜力，研究人员必须测量与人类诊断医学相同的基本临床化学参数。杰克逊实验室（TJL）的工作人员在定义标准近亲繁殖小鼠的规范生物学和描述数百种具有生物医学意义的新突变方面处于最前沿。临床实验室测定对于TJL工作人员开发的许多新的自交系和同源系以及许多新的自发和诱导突变的表型表征至关重要。TJL目前还没有这样的仪器。一种自动化临床化学分析仪，Synchron Cx5 Delta, Beckman Instruments, Brea， CA，已经证明了其在人类诊断医学中的可靠性。由于它只需要少量的血清、血浆或尿液，因此该分析仪将满足TJL工作人员对这些生物液体中各种常见生化分析物的测量需求。Cx5 Delta是测量这些相关生理参数的一种经济有效的机制。在TJL，超过86%的研究项目集中在遗传疾病的分析上。这些包括由单基因突变引起的综合征或更复杂的多因素遗传疾病，如癌症、糖尿病和动脉粥样硬化。这样的研究产生了数百个后代，在这些后代中，可以观察到复杂性状的连续变化。在这些群体中精确测量相关的生化亚表型分离是必不可少的。与各种生化参数的自动收集相关的研究进展将大大增强当前的项目。申请资金用于购买Beckman Synchron Cx5系统，该系统将由该机构的微化学服务处按服务收费操作，从而提供一种具有成本效益的方式，以满足TJL工作人员目前尚未满足的紧急需求。

New genetic technologies combined with a well characterize genome make the mouse the preferred mammalian model for human disease. Investigators must be able to characterize them genetically and physiologically to exploit their full biomedical potential. To realize this potential, investigators must measure the same basic clinical chemistry parameters used in human diagnostic medicine. The staff of The Jackson Laboratory (TJL) is at the forefront both in defining the normative biology of standard inbred mice and in characterizing hundreds of new mutations of biomedical significance. Clinical laboratory determinations are essential for phenotypical characterization of the many new inbred strains and congenic lines developed by TJL Staff, and many new spontaneous and induced mutations. No such instrumentation currently exists at TJL. An automated clinical chemistry analyzer, the Synchron Cx5 Delta, Beckman Instruments, Brea, CA, has proven its reliability in human diagnostic medicine. Because it requires only small volumes of serum, plasma, or urine, this analyzer would meet the needs of TJL staff for measurement of a variety of common biochemical analytes in these biological fluids. The Cx5 Delta represents a cost-efficient mechanism for measuring these relevant physiologic parameters. At TJL more than 86% of research projects focus on the analysis of genetic disease. These include either syndromes caused by single gene mutations or more complex, multifactorial genetic diseases, such as cancer, diabetes, and atherosclerosis. Such studies generate many hundreds of progeny in which continuous variation in a complex trait is observed. Accurate measurement of relevant biochemical sub-phenotypes segregating in these populations is essential. Research progress associated with automated collection of a variety of biochemical parameters would greatly enhance current projects. Funds are requested to purchase the Beckman Synchron Cx5 System, to be operated by the institution's Microchemistry Service on a fee for service basis thus providing a cost-effective way to fill an urgent, and currently unmet need of TJL staff.