SYNTHESIS OF NEW TITANIUM, PLATINUM, AND RUTHENIUM ANTICANCER DRUGS

描述（改编自应用程序）：电位合成 抗癌药物，包括糖醇盐和羧酸盐复合物， 钛、铂和钌以及铂的羧酸盐络合物 含有有机锡碎片的化合物。糖醇盐 络合物可以由相应的 氯或碳酸盐与相应的阿利多醇的络合物。的 羧酸盐络合物可以由以下物质的反应获得： 相应的糖醇盐或碳酸盐与相应的 羧酸含铂羧酸盐配合物 有机锡片段可以由以下反应合成： 相应的铂羧酸与相应的有机锡 氢氧化物或相应的有机锡羧酸。的 钛、铂和钌络合物将通过UV- 维斯，IR和NMR光谱和钌络合物将被 通过UV-Vis、IR和NMR光谱以及元素分析进行表征。 这些复合物的毒性水平将在约翰斯 霍普金斯大学。这些药物的细胞毒性和抗增殖作用 复合物将在南方研究中心的细胞系上进行测试。 院该项目的长期目标是合成各种 钛、铂和钌羧酸盐络合物，其含有 有机锡片段，这将导致广泛的发展 潜在的抗癌药物。

Description (Adapted from Application): Synthesis of potential anticancer drugs which include alditolate and carboxylate complexes of titanium, platinum, and ruthenium and carboxylate complexes of platinum containing organotin fragments will be attempted. The alditolate complexes may be synthesized from the reactions of the corresponding chloro or carbonate complexes with the corresponding alidotols. The carboxylate complexes may be obtained from the reactions of the corresponding alditolate or carbonate complexes with the corresponding carboxylic acids. The carboxylate complexes of platinum containing organotin fragment may be synthesized from the reactions of either the corresponding platinum carboxylic acids with the corresponding organotin hydroxides or the corresponding organotin carboxylic acids. The titanium, platinum, and ruthenium complexes will be characterized by UV- Vis, IR, and NMR spectra and by ruthenium complexes will be characterized by UV-Vis, IR, and NMR spectra and by elemental analysis. The levels of toxicity of these complexes will be measured at Johns Hopkins University. The cytotoxic and antiproliferative effects of these complexes will be tested on cell lines at the Southern Research Institute. The long-term goal of this project is to synthesize a variety of titanium, platinum, and ruthenium carboxylate complexes containing organotin fragments which will lead to the development of a broad range of potential anti-cancer drugs.