STRUCTURE/FUNCTION CORRELATIONS IN TISSUE GAS EXCHANGE

组织气体交换中的结构/功能相关性

• 批准号: 6107603
• 负责人: ODILE A MATHIEU-COSTELLO
• 金额: $ 5.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6107603
• 关键词: animal tissue; blood; capillary; diffusion; digital imaging; histochemistry /cytochemistry; membrane permeability; mitochondria; morphology; muscle function; myocardium; myofibrils; oxygen consumption; oxygen transport; physiology; respiratory gas transport; respiratory oxygenation

The overall objective is to better understand structure-function interactions in the design and capacity of muscles for blood-tissue exchange. We developed methods to assess several aspects of muscle capillary-fiber morphometrics. We will train students to use these methods, together with histochemical characterization of capillary heterogeneity to explore myocardial structural capacity for O2 flux and study its limit in relation to fiber oxygen demand. This project will focus on rat and rabbit heart, with comparison with birds and bats to explore natural differences in muscle aerobic capacity and degree of capillarization. Our central hypothesis is that it is the size of the capillary-fiber interface, not diffusion distances, which determine O2 flux rates in aerobic muscles. Data in the highly aerobic myocardium will be important correlates to our ongoing studies of skeletal muscles with large differences in fiber type distribution, clustering and aerobic capacity, including locomotory muscles of terrestrial mammals and flight muscles in bird and bat. It should provide new insights in the understanding of key aspects of structure-function correlations in muscle capacity for blood-tissue transfer, and should help in the understanding and management of human response to impaired tissue oxygenation.

总体目标是更好地理解结构功能 血液组织肌肉的设计和能力之间的相互作用 交换。我们开发了评估肌肉多个方面的方法 毛细管纤维形态测量。我们将训练学生使用这些 方法，以及毛细血管的组织化学表征 异质性以探索心肌的 O2 通量结构能力和 研究其与纤维需氧量相关的极限。该项目将 重点关注大鼠和兔子的心脏，并与鸟类和蝙蝠进行比较 探索肌肉有氧能力和程度的自然差异 毛细血管化。我们的中心假设是，它的大小 毛细管-纤维界面，而不是扩散距离，决定了 O2 有氧肌肉的通量率。高氧心肌中的数据将 与我们正在进行的骨骼肌研究具有重要的相关性 纤维类型分布、聚集和有氧方面存在较大差异 能力，包括陆地哺乳动物的运动肌和飞行 鸟类和蝙蝠的肌肉。它应该提供新的见解 了解肌肉结构-功能相关性的关键方面 血液组织转移的能力，应该有助于理解 和管理人体对组织氧合受损的反应。