CORE--DEVELOPMENTAL

CFAR发展核心的目的是刺激 凯斯西储大学的艾滋病相关研究及其 通过促进翻译性基础/临床研究开发来建立分支机构 应用将促进艾滋病相关工作的实验技术 研究，促进与Case WESTERN其他中心的互动 预备役大学校园。发展型核心行政结构 已经建立了分发和监测发展的使用情况 通过各种机制提供资金，包括(1)由调查员发起 可行性研究，(2)请求具体应用，(3)新的 技术开发，(4)教师招聘，(5)最先进的核心 开发，(6)CFAR补充应用，和(7)中心间 协调。 作为三年期间发展核心活动的结果，12 新成员加入CFAR，已发表5篇稿件，5 国家研究补助金，直接费用共计290万美元(包括 1名少数民族补充补助金)已获得资助，两名新教职员工 专注于与艾滋病相关的研究已被招募到凯斯韦斯特 储备大学，Elispot的一项技术已获得凯斯的专利 西部储备大学，作为一项服务由新的CFAR提供 细胞因子核心，三个其他CFAR核心已得到增强，并有几个 已经制定了中心间方案倡议。 请拨150 000美元/年的发展核心资金用于06-10年度至 用于支持上文概述的发展核心计划。在……里面 06年度，75,000元将用于招聘教员和剩余的 用于支持调查员发起的可行性研究和核心 发展。2006年及以后几年，发展核心基金 将由CFAR领导层酌情在 资金可能对刺激艾滋病相关人员产生最大影响的地方 研究活动。

The purpose of the CFAR Developmental Core is to stimulate the growth of AIDS-related research at Case Western Reserve University and its affiliates by fostering translational basic/clinical research developing experimental technologies whose application will advance AIDS-related research, promoting interactions with other Centers on the Case Western Reserve University campus. A Developmental Core administrative structure has been established to distribute and monitor the use of developmental funds through a variety of mechanisms including (1) investigator initiated feasibility studies, (2) request for specific applications, (3) new technology development, (4) faculty recruitment, (5) state-of-the-art core development, (6) CFAR supplement applications, and (7) inter-center coordination. As a result of Developmental Core activities over a three year period, 12 new members have joined the CFAR, 5 manuscripts have been published, 5 national research grants totaling $2.9 million in direct costs, (including 1 minority supplement grant) have been funded, two new faculty members with a focus on AIDS-related research have been recruited to Case Western Reserve University, an ELIspot technology has been patented by Case Western Reserve University and provided as a service by a new CFAR Cytokine Core, thre other CFAR Cores have been enhanced, and several inter-center program initiatives have been developed. Developmental Core funds of $150,000/year are requested for years 06-10 to be used to support the Developmental Core programs as outlined above. In year 06, $75,000 will be used for faculty recruitment and the remained used to support investigator initiated feasibility studies and core development. In year 06 and in subsequent years, developmental Core funds will be distributed at the discretion of the CFAR leadership on a basis where the funds may have the greatest impact in stimulating AIDS-related research activities.