ALL'S FAIR WHEN LOVE IS WAR: THE EVOLUTION OF LIFESPAN AND AGEING UNDER SEXUAL CONFLICT.

当爱情是战争时，一切都是公平的：性冲突下寿命和衰老的演变。

• 批准号: NE/K004697/1
• 负责人: Tracey Chapman
• 金额: $ 55.5万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FK004697%2F1
• 关键词: FAIR; WHEN; LOVE; WAR; EVOLUTION

In 1992 John Gray wrote a now famous book 'Men are from Mars, Women are from Venus' (Harper Collins). In this he illustrated the many differences between males and females using the book title as the central metaphor. He imagined that the sexes are so different that one might as well consider them as originating from different planets. One of the main ideas in the book is that men and women assess or 'score' the currency of their relationship - but that they score according to different scales! This is evident, Gray suggests, when the amount of give and take within a relationship is not assessed or scored equitably. This can lead to a perceived or actual imbalance in the relationship, leading to resentment and so on. Overall, the ideas in this book proved to be a popular way of thinking about how relationships work - or not - in terms of sex differences.Whatever one thinks about the book and its legacy, the central ideas described above accord surprisingly well with evidence drawn from plants and animals. It was realised in the 1970s, for example, that rather than being co-operative ventures, the interactions between the sexes over reproduction are often characterized by conflict rather than co-operation. Hence the sexes often 'disagree' about how much energy and resources to invest in reproduction and how often to make that investment. A good example is evolutionary disagreements over how often to mate. Males often gain from mating frequently and females often do not. Furthermore, females often suffer significantly reduced lifespan from mating too frequently (an effect that we now know is also true in humans). Such lifespan reduction arising from mating frequently is not incurred to anything like the same degree in males.It has recently been realised that these sexual interactions, i.e. the effect of males on female lifespan and vice versa, could actually underlie an important and long-standing puzzle: why it is that males and females often have very different longevity. For example, human females generally live at least 4 years longer than men. Such sex differences are also extremely common in the animal world, and can occur in either direction.In experimental settings the way that lifespan is measured, and longevity 'genes' identified, is often to use non-reproductive individuals, or those that are mated early in life and then kept away from the other sex. Such tests are therefore missing something important - the effects of regular exposure to the other sex.It is now believed that the 'sexual conflicts' of the sort described by Gray and earlier considered by evolutionary biologists such as Geoff Parker, Richard Dawkins and Bill Rice can go a long way to explaining sex differences in lifespan and ageing by considering the effects of one sex upon the other.The central aim of the research proposed here is to evaluate this idea and to examine the underlying genetic basis of the differences in these necessary, but sometimes dangerous, liaisons between the sexes.The work is important because it will be the first full test of these ideas and the first to probe the genomic basis of sex differences caused by sexual conflict. Our proof of principle data gathered for this proposal show that the methods proposed can identify novel ageing genes. The work is also useful because these ideas can also be fed directly into husbandry practices for pest control in the applied sector.Overall this is an exciting and novel project that will test whether sexual conflict can lead to increased ageing and will identify the underlying genes that are responsible.

1992年约翰·格雷写了一本现在很有名的书《男人来自火星，女人来自金星》（哈珀柯林斯）。在这本书中，他用书名作为中心隐喻，说明了男性和女性之间的许多差异。他想象两性是如此不同，以至于人们可以认为它们来自不同的星球。书中的一个主要观点是，男人和女人评估或“评分”他们的关系的货币-但他们根据不同的尺度评分！格雷认为，当一段关系中的付出和索取的数量没有得到公平的评估或评分时，这是显而易见的。这可能会导致两性关系中的感知或实际不平衡，导致怨恨等。总体而言，这本书中的观点被证明是一种流行的思考方式，可以从性别差异的角度来思考两性关系是如何运作的--或者说是如何运作的。无论人们如何看待这本书及其遗产，上面描述的中心思想都与从植物和动物中得出的证据惊人地一致雅阁。例如，人们在20世纪70年代意识到，两性之间在生殖方面的互动往往不是合作，而是冲突。因此，两性在生殖上投入多少能量和资源以及多久进行一次投资的问题上常常“意见不一”。一个很好的例子是关于交配频率的进化分歧。雄性通常从频繁的交配中获益，而雌性通常不会。此外，女性经常因过于频繁的交配而显著缩短寿命（我们现在知道这种影响在人类中也是如此）。这种由于频繁交配而导致的寿命缩短在男性身上并没有达到同样的程度。最近人们意识到，这些性的相互作用，即男性对女性寿命的影响，反之亦然，实际上可能是一个重要的和长期存在的谜团的基础：为什么男性和女性的寿命往往非常不同。例如，人类女性通常比男性多活至少4年。这种性别差异在动物世界中也非常普遍，而且可能发生在任何一个方向。在实验环境中，测量寿命的方式，以及长寿“基因”的鉴定，通常是使用非生殖个体，或者那些在生命早期交配，然后远离另一性别的个体。因此，这样的测试忽略了一些重要的东西--经常接触异性的影响。现在人们认为，格雷描述的那种“性冲突”，以及杰夫帕克等进化生物学家早些时候考虑过的那种“性冲突”，理查德·道金斯和比尔·赖斯通过考虑一种性别对另一种性别的影响，可以在很大程度上解释寿命和衰老方面的性别差异。本研究的目的是评估这一观点，并研究两性之间这些必要的、但有时也是危险的关系中存在的差异的潜在遗传基础。这项工作很重要，因为它将是对这些观点的第一次全面检验，也是第一次探索由性冲突引起的性别差异的基因组基础。我们为这项提议收集的原理数据证明，所提出的方法可以识别新的衰老基因。这项工作也是有用的，因为这些想法也可以直接用于应用部门的虫害控制的畜牧实践。总的来说，这是一个令人兴奋的和新颖的项目，将测试性冲突是否会导致增加衰老，并将确定潜在的基因负责。

项目成果

Sex ratio and the evolution of aggression in fruit flies.

• DOI: 10.1098/rspb.2020.3053
• 发表时间: 2021-03-31
• 期刊: Proceedings. Biological sciences
• 作者: Bath E;Edmunds D;Norman J;Atkins C;Harper L;Rostant WG;Chapman T;Wigby S;Perry JC
• 通讯作者: Perry JC

The Genetics and Biology of Sexual Conflict

性冲突的遗传学和生物学

• 发表时间: 2014
• 作者: Hurst, GDD & Frost, CL

Sexual selection and the evolution of condition-dependence: an experimental test at two resource levels.

性选择和条件依赖性的进化：两个资源水平的实验测试。

• DOI: 10.1093/evolut/qpac066
• 发表时间: 2023
• 期刊: Evolution; international journal of organic evolution
• 作者: Bath E

Manipulation of feeding regime alters sexual dimorphism for lifespan and reduces sexual conflict in Drosophila melanogaster.

• DOI: 10.1098/rspb.2017.0391
• 发表时间: 2017-05-17
• 期刊: Proceedings. Biological sciences
• 作者: Duxbury EML;Rostant WG;Chapman T
• 通讯作者: Chapman T

Running with the Red Queen: the role of biotic conflicts in evolution.

• DOI: 10.1098/rspb.2014.1382
• 发表时间: 2014-12-22
• 期刊: Proceedings. Biological sciences
• 作者: Brockhurst MA;Chapman T;King KC;Mank JE;Paterson S;Hurst GD
• 通讯作者: Hurst GD