IMAGING OF MYOCARDIAL INFARCTS IN SUDDEN DEATH

猝死时心肌梗塞的影像学检查

• 批准号: 6123454
• 负责人: EDWARD G WALSH
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123454
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biomedical resource; building /facility design /renovation; eye; magnetic resonance imaging; nervous system; technology /technique

A significant problem in functional MRI (fMRI) studies is a satisfactory means of presenting visual stimuli within the confines of the MRI system, and presenting these stimuli stereoscopically and at high spatial resolution. A second difficulty is the need for monitoring of gaze direction in fMRI studies of the oculomotor system, in which accuracy of oculomotor responses is of great importance in interpretation of fMRI results. An additional difficulty in visual presentation is monitoring compliance with instructions as to gaze direction, which can be crucial to interpretation of fMRI results in studies of the visual system. In this project these problems are answered with the construction of a unique optical system compatible with the hardware of the UAB 4.1T MRI system. The system under construction includes a pair of high-resolution LCD screens (800x600) to be viewed by an integrated binocular optical system, which will include an adaptation of an existing computer-controlled ISCAN video-camera-based system for monitoring eye movements and gaze direction. Installation is scheduled for May 1998. Preliminary oculomotor fMRI results obtained prior to the installation of the optical system have been reported in Kidambi S et al., fMRI Detection of Frontal Eye Field Activation during Saccadic Eye Movements, Proc Intl Soc Magn Reson Med 1844, 1996.  The optical system will be invaluable in oculomotor and vision-related fMRI studies and in many fMRI studies where non-verbal responses are required. It will also allow visual studies of stereopsis and depth perception. A system with this capability will thus find broad application in fMRI studies at many institutions. Development of this system will not only significantly enhance fMRI studies at the University of Alabama at Birmingham, but will also allow investigators at other institutions to be provided with the technology to significantly enhance their fMRI studies.

功能磁共振成像(FMRI)研究中的一个重要问题是 在以下范围内呈现视觉刺激的令人满意的方法 核磁共振系统，并以立体方式和在 高空间分辨率。第二个困难是需要 眼球运动系统功能磁共振研究中注视方向的监测， 其中，眼动反应的准确性在 功能磁共振成像结果的解释。视觉上的另一个困难 演示是监控凝视指令的遵从性 方向，这可能是解释fMRI结果的关键 对视觉系统的研究。在这个项目中，这些问题是 以独特的光学系统兼容的结构回答 使用UAB 4.1T磁共振系统的硬件。 正在建设的系统包括一对高分辨率的 LCD屏幕(800x600)可通过集成双目光学系统观看 系统，其中将包括对现有 基于计算机控制的Iscan摄像机眼部监控系统 动作和凝视方向。安装计划于1998年5月进行。 在手术前获得的初步动眼功能磁共振检查结果 光学系统的安装已在基丹比报道，S等人 眼球跳动时额叶眼场激活的fMRI检测 眼球运动，《国际眼科杂志》，1844,1996。光学的 该系统将在眼球运动和视觉相关的功能磁共振成像中发挥不可估量的作用 研究和许多功能磁共振研究中，非语言反应 必填项。它还将允许对立体视觉和深度进行视觉研究 感知力。因此，具有这种能力的系统将发现广泛的 在许多机构的功能磁共振研究中的应用。这方面的发展 系统不仅将显著提高fMRI研究在 阿拉巴马大学伯明翰分校，但也将允许调查人员 在其他机构提供该技术，以 大大提高了他们的功能磁共振研究。