CONTROL OF VERGENCE EYE MOVEMENTS BY THE FRONTAL CORTEX

额叶皮层对眼球运动的控制

• 批准号: 6299097
• 负责人: James R Dearworth
• 金额: $ 3.24万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6299097
• 关键词: Macaca mulatta; binocular vision; eye coordination disorder; eye movements; frontal lobe /cortex; neural information processing; neurons; orientation; space perception; visual perception

Alert, rhesus monkeys will be trained to perform oculomotor tasks to clarify how neurons within the prearcuate cortex (8Ar) encode the visual characteristics of binocular stimuli that elicit vergence eye movements. Visually-guided vergence eye movements are reported to be composed of an initial transient vergence component and a later, sustained fusional component that "locks" vergence angle sufficiently for sensory fusion to occur. These components have been studied extensively in humans but not in the rhesus monkey. Initially, these components of vergence eye movements will be characterized in monkeys using the electromagnetic search coil method. Subsequently, these vergence components and the sensory stimuli eliciting them will be correlated with single-unit activity recorded from neurons within the prearcuate cortex. I. The first aim will characterize the behavior of neurons within the prearcuate cortex during the transient and sustained components of vergence. Briefly presented dichoptic images or long presentations of dissimilar images will separate transient vergence from sustained vergence. II. The second aim will look more closely at those visual characteristics encoded by neurons within the prearcuate cortex. A forced-choice paradigm will be used to determine what target characteristics (e.g. luminance, orientation, spatial frequency) affect transient vergence and neural activity. III. The final aim uses dichoptic stimuli that dissociate binocular matches based on local and global cues during transient vergence. Correlated, dynamic random-dot stereograms will test how prearcuate neurons respond to these global disparity cues. The results of this project will improve our understanding of neurological deficits associated with strabismus and of vergence dysfunction.

警惕的恒河猴将被训练执行动眼神经任务，以阐明前弓状皮层 (8Ar) 内的神经元如何编码引起眼球聚散运动的双眼刺激的视觉特征。据报道，视觉引导的聚散眼运动由最初的瞬时聚散分量和随后的持续融合分量组成，该融合分量足以“锁定”聚散角以发生感觉融合。这些成分已在人类身上进行了广泛研究，但尚未在恒河猴身上进行过研究。最初，将使用电磁搜索线圈方法在猴子中表征这些聚散眼球运动的组成部分。随后，这些聚散成分和引起它们的感觉刺激将与从前弓状皮层内的神经元记录的单个单元活动相关。 I.第一个目标将描述前弓状皮层内神经元在短暂和持续的聚散过程中的行为。简短呈现的二分视图像或长时间呈现不同的图像将区分瞬时聚散和持续聚散。二.第二个目标将更仔细地研究由前弓状皮层内的神经元编码的视觉特征。将使用强制选择范例来确定哪些目标特征（例如亮度、方向、空间频率）影响瞬态聚散度和神经活动。三．最终目标是使用二眼刺激，在短暂的聚散期间根据局部和全局线索分离双眼匹配。相关的动态随机点立体图将测试前弓形神经元如何响应这些全局差异线索。该项目的结果将提高我们对与斜视和聚散功能障碍相关的神经缺陷的理解。