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IKAROS REGULATES VASOACTIVE INTESTINAL PEPTIDE RECEPTOR

IKAROS REGULATES VASOACTIVE INTESTINAL PEPTIDE RECEPTOR
IKAROS 调节血管活性肠肽受体
批准号：
6207615
负责人：
GLENN Paul DORSAM
金额：
$3.75万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
未结题
起止时间：
2000-09-01 至
来源：
https://reporter.nih.gov/project-details/6207615
关键词：
DNA footprinting T lymphocyte antileukemic agent binding sites biological signal transduction cell growth regulation cell line gel mobility shift assay gene induction /repression genetic promoter element hemolymph neoplasm /cancer genetics neuropeptide receptor protein isoforms protein structure function receptor expression transcription factor vasoactive intestinal peptide

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中文摘要
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英文摘要
The zinc-finger hemolymphopoietic-restricted transcription factor, Ikaros, is mutated in some human leukemias. Moreover, genetic deletions of the Ikaros DNA-binding domain were associated with an aggressive T lymphocyte leukemia in mice. Thus, the transcriptional regulation of growth-modulating genes by Ikaros may be an important underlying cause for the development of certain leukemias. Recently, we have collected novel data suggesting that Ikaros transcriptionally regulates the expression of VIP-PACAP receptor 1 (VPAC-1), which has been demonstrated to transmit anti-proliferative signals. Therefore, we propose to investigate the transcriptional regulation of VPAC-1 by Ikaros in T lymphocytes.
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Eosinophil trafficking in fungal allergic asthma
  • 批准号：
    8496369
  • 项目类别：
  • 资助金额：
    $43.48万
  • 财政年份：
    2013
  • 负责人：
    GLENN Paul DORSAM
  • 依托单位：
    NORTH DAKOTA STATE UNIVERSITY
COBRE: NDSU: PROJECT 1: EPIGENETIC REGULATION OF VASOACTIVE INTESTINAL PEPTIDE
  • 批准号：
    8360593
  • 项目类别：
  • 资助金额：
    $13.69万
  • 财政年份：
    2011
  • 负责人：
    GLENN Paul DORSAM
  • 依托单位：
    NORTH DAKOTA STATE UNIVERSITY
COBRE: NDSU: PROJECT 1: EPIGENETIC REGULATION OF VASOACTIVE INTESTINAL PEPTIDE R
  • 批准号：
    8167860
  • 项目类别：
  • 资助金额：
    $13.83万
  • 财政年份：
    2010
  • 负责人：
    GLENN Paul DORSAM
  • 依托单位：
    NORTH DAKOTA STATE UNIVERSITY
HETEROCHROMATIN RECRUITMENT OF THE VPAC1 LOCUS BY IKAROS
  • 批准号：
    7985275
  • 项目类别：
  • 资助金额：
    $5.32万
  • 财政年份：
    2010
  • 负责人：
    GLENN Paul DORSAM
  • 依托单位：
    NORTH DAKOTA STATE UNIVERSITY
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