PATHLENGTH RESOLVED NONINVASIVE OPTICAL GLUCOSE SENSORS

光程分辨无创光学葡萄糖传感器

• 批准号: 6078311
• 负责人: JOSEPH A IZATT
• 金额: $ 11.25万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6078311
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biosensor device; clinical biomedical equipment; glucose; interferometry; monitoring device; optics; tomography

DESCRIPTION (Adapted from applicant's abstract): The objective of this proposal is to investigate coherent optical technology for monitoring glucose concentration. The proposed advances take the advantage of the intrinsic optical path selectivity of optical coherence tomography (OCT), a recently developed technology for quantitative, non-invasive tissue sensing and imaging based on low-coherence interferometry. Methods for monitoring tissue index of refraction, scattering and polarization changes are proposed which feature explicit control over sampled tissue path length. The specific aims of the proposal are to: 1) test the feasibility of three new concepts for micron-scale path-length-resolved, non-invasive optical glucose sensing based upon adaptations of optical coherence tomography (OCT), 2) correlate the measurements with actual glucose concentrations in simple and increasingly complex tissue fluid models, as well as in human volunteers undergoing glucose challenge tests. Each of the proposed technical approaches is completely non-invasive, requiring no withdrawal of blood or subcutaneous fluid and do not require disposable supplies or re-stocking of enzymes.

描述（改编自申请人摘要）：本研究的目的 建议是研究相干光技术用于监测 葡萄糖浓度拟议的进展利用了 光学相干层析成像（OCT）固有光路选择性， 一种最近开发的定量非侵入性组织 基于低相干干涉测量的传感和成像。方法 监测组织折射率、散射和偏振变化 提出了对采样组织路径进行显式控制的方法 长度具体目标是：1）检验可行性 三个新的概念，微米级的路径长度分辨，非侵入性 基于光学相干自适应的光学葡萄糖感测 断层扫描（OCT），2）将测量值与实际葡萄糖 在简单和日益复杂的组织液模型中， 以及在进行葡萄糖激发试验的人类志愿者中。中的每 所提出的技术方法是完全非侵入性的，不需要 抽取血液或皮下液体，不需要一次性用品 供应或重新储存酶。