REGULATION OF EMMETROPIZATION

这些研究的长期目标是确定有效的 屈光状态疾病的预防或管理策略 (i.e.近视）。 近视（近视），一种临床状况， 眼睛相对于眼睛的屈光力生长得太长， 它的光学成分，是最常见的眼科疾病， 世界 它的经济和公共卫生影响是巨大的 （仅美国人就花费近20亿美元用于屈光不正。 每年都要改正）。 一场科学争论已经持续了 世纪屈光状态（例如近视， 眼睛的视觉输入可以影响眼睛的视力。 来自临床研究和动物模型的证据表明， 眼睛的屈光发育受到视觉的影响 体验. 然而，尚待确定的是 用来调节眼睛生长的信号。 作为第一步， 使用237只正常饲养的猴子测定正常的眼睛生长， 其年龄范围从出生到5岁（年轻成人）。 数据 支持遗传学和环境在调控中的作用 正视化（即正常眼睛生长的过程， 屈光发育）。 然后，这些基线数据被用于 研究了15只猴子未经处理的眼睛的发育情况， 用三种不同的对侧眼视觉操作之一。 尽管有正常的视觉输入，未经治疗的眼睛不同 系统地在屈光不正和轴向长度，根据 他们的眼睛受到的待遇。 我确已建立了 未来的眼睛生长模型不仅要考虑 视觉输入对眼睛直接影响，但也有间接影响， 视觉输入对另一只眼睛的影响。 为了努力 为了进一步研究，设计了一种独特的头盔和护目镜， 饲养了四只视觉操作更好的猴子。 其中，三个 在双眼输入不相等的情况下饲养（一只眼睛散焦， 只有光输入或没有对侧眼的光输入）。 虽然这些 数据提供了新的证据，说明在 调节正视化，他们也支持这样的概念， 而不是简单地试图在物理长度上“匹配”两只眼睛 或屈光状态，眼间影响实际上可能是 对视觉输入的质量很敏感。 资助NIH RR 00165 50，000美元1995年7月1日至1999年6月30日出版物布拉德利，D. V.，Fernandes，A.， 林恩，M.，Tigges，M. Boothe，R.G.恒河猴的正视化 猴（Macaca mulatta）：出生到青年期。 Invest. 眼用酚 维斯。Sci. (In Press）。 P51 RR 00165 -38 1998年1月1日至1998年12月31日 耶基斯地区灵长类动物研究中心

The long term goal of these studies is to identify effective preventive or management strategies for disorders of refractive status (i.e. myopia). Myopia (nearsightedness), a clinical condition in which the eye grows too long in relation to the refractive power of its optical components, is the most common ophthalmic disorder in the world. Its economic and public health impact are tremendous (Americans alone spend nearly 2 billion dollars for refractive error correction each year). A scientific debate has existed for over a century about whether the refractive status (e.g. nearsighted, farsighted) of the eye can be influenced by its visual input. Converging evidence from clinical studies and animal models has shown that the refractive development of the eye is influenced by visual experience. What has yet to be determined, however, is the nature of the signal that is used to regulate eye growth. As a first step, normal eye growth was determined using 237 norma lly reared monkeys, whose ages ranged from birth to 5 years (young adult). The data supported a role for both genetics and environment in the regulation of emmetropization (i.e. the process of normal eye growth and refractive development). These baseline data were then used to examine the development of the untreated eyes of 15 monkeys reared with one of 3 different visual manipulations of the fellow eyes. Despite having normal visual input, the untreated eyes differed systematically in refractive error and axial length, according to the treatment received by their fellow eyes. Thus, we have established that future models of eye growth will have to consider not only the direct influence of visual input on that eye, but also the indirect influence of the visual input to the fellow eye. In an effort to study this further, a unique helmet and goggle design was created to rear four monkeys with improved visual manipulations. Of those, three were reared with unequal binocular input (defocused in put of one eye, light input only or no light input of the fellow eye). While these data provided new evidence for an interocular influence in the regulation of emmetropization, they also support the notion that rather than simply trying to "match" the two eyes in physical length or refractive status, the interocular influence may in fact be sensitive to the quality of the visual input. FUNDING NIH RR00165 $50,000 7/01/95 - 6/30/99 PUBLICATIONS Bradley, D.V., Fernandes, A., Lynn, M., Tigges, M. and Boothe, R.G. Emmetropization in the rhesus monkey (Macaca mulatta) Birth to young adulthood. Invest. Ophthalmol. Vis. Sci. (In press). P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center