MONKEY MODEL OF LATE ONSET MYOPIA

在生命早期，在对应于快速婴儿期的年龄 在人类的眼球生长中，视觉反馈可以调节屈光 在猴子和许多其他物种中的发展。 以确定是否 视觉依赖机制仍然可以影响屈光发育 在灵长类动物中，在眼睛生长的缓慢幼年期， 在人类儿童近视发展的典型时期，我们检查了 模式化视觉剥夺对青少年猴子的影响。 视力剥夺的发病年龄在3.7岁至5岁之间， 其对应于发病年龄在约15至20岁之间。 的 通过睫状肌麻痹剂评估图形剥夺的眼部效应 视网膜检影和A型超声检查。 在模式开始时 剥夺时，所有4只猴子都是等屈光的（在剥夺时屈光不正相等）。 左眼和右眼），2只眼的眼轴尺寸为 很相配。 经过71至80周的模式剥夺，所有的 视力受损的眼睛变得相对更近视， 他们的未接受治疗的眼睛，并且他们的视力相对增加 玻璃体腔深度和眼轴长度。 因此，我们现在有 研究表明，视觉依赖机制可以影响视力， 在“青少年”猴子中的生长和屈光发育。 这些结果 提高了视觉体验可能参与的可能性， 儿童学龄期近视的成因。 资助大学 休斯顿$10，000 96年9月1日-99年4月30日出版物Smith，EL III，布拉德利， D.V.，Fernandes，A. Boothe，R.G.形觉剥夺性近视 青春期的猴子 Optom。 维斯。Sci. (In Press）。 P51RR00165-38 1998年1月1日至1998年12月31日耶基斯地区灵长类动物研究中心

Early in life, at ages corresponding to the rapid infantile phase of ocular growth in humans, visual feedback can modulate refractive development in monkeys and many other species. To determine if vision-dependent mechanisms can still influence refractive development in primates during the slow juvenile phase of ocular growth, the time period when myopia typically develops in human children, we examined the effects of patterned visual deprivation on adolescent monkeys. The onset of visual deprivation was between 3.7 and 5 years of age, which corresponds to onset ages between about 15 and 20 years. The ocular effects of pattern deprivation were assessed by cycloplegic retinoscopy and A-scan ultrasonography. At the onset of pattern deprivation, all 4 monkeys were isometropic (equal refractive error in the left and right eyes) and the axial dimensions in the 2 eyes were well matched. Following 71 to 80 weeks of pattern deprivation, all of the visually deprived ey es had bec ome relatively more myopic than their fellow non-treated eyes and they exhibited relative increases in vitreous chamber depth and axial length. Therefore, we have now demonstrated that vision-dependent mechanisms can influence ocular growth and refractive development in "teenage" monkeys. These results raise the possibility that visual experience may be involved in the genesis of school-age myopia in children. FUNDING University of Houston $10,000 9/01/96 - 4/30/99 PUBLICATIONS Smith, EL III, Bradley, D.V., Fernandes, A. and Boothe, R.G. Form deprivation myopia in adolescent monkeys. Optom. Vis. Sci. (In press). P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center